Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 910161..910614 Replicon chromosome
Accession NZ_CP076596
Organism Erwinia amylovora isolate CP20161301

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KQH32_RS04080 Protein ID WP_013035888.1
Coordinates 910161..910397 (-) Length 79 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D4HZA2
Locus tag KQH32_RS04085 Protein ID WP_004159527.1
Coordinates 910387..910614 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH32_RS04060 (KQH32_04080) 905676..906554 - 879 WP_004159509.1 Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD -
KQH32_RS04065 (KQH32_04085) 906569..907363 - 795 WP_004159512.1 Fe3+-hydroxamate ABC transporter ATP-binding protein FhuC -
KQH32_RS04070 (KQH32_04090) 907412..909628 - 2217 Protein_784 ferrichrome porin FhuA -
KQH32_RS04075 (KQH32_04095) 909956..910174 + 219 WP_004159522.1 hypothetical protein -
KQH32_RS04080 (KQH32_04100) 910161..910397 - 237 WP_013035888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQH32_RS04085 (KQH32_04105) 910387..910614 - 228 WP_004159527.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KQH32_RS04090 (KQH32_04110) 910935..911222 + 288 WP_004159528.1 SymE family type I addiction module toxin -
KQH32_RS04095 (KQH32_04115) 911286..911690 - 405 WP_013035886.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-78)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-75)


Sequences

Toxin        


Download         Length: 79 a.a.        Molecular weight: 9135.79 Da        Isoelectric Point: 9.0876

>T206022 WP_013035888.1 NZ_CP076596:c910397-910161 [Erwinia amylovora]
ISYELLFDPWALKEWKKLGATVREQFKKKLAEVLVNLQVESARLRDHPDCCKIKLKSSGYRLVYQVQDEQLVMLVISV

Download         Length: 237 bp

>T206022 NZ_CP102070:c2640852-2640751 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8435.90 Da        Isoelectric Point: 7.9766

>AT206022 WP_004159527.1 NZ_CP076596:c910614-910387 [Erwinia amylovora]
VRLDDKLKSKACAVLDELDVSPTEAVRLLFQYIAENERLPLKALTVSDEKDALLKTVRERLASLQKGIKVTLDKL

Download         Length: 228 bp

>AT206022 NZ_CP102070:2640629-2640806 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGATTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A831A410

References