205950

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1668..2142 Replicon plasmid p8
Accession NZ_CP076552
Organism Klebsiella pneumoniae strain 19PDR22

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag HF574_RS28445 Protein ID WP_004197762.1
Coordinates 1876..2142 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag HF574_RS28440 Protein ID WP_000879771.1
Coordinates 1668..1892 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF574_RS30510 1..5596 - 5596 WP_032433971.1 hypothetical protein -
HF574_RS28430 (HF574_29165) 273..782 + 510 WP_032433972.1 MbeB family mobilization protein -
HF574_RS28435 (HF574_29170) 789..1001 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
HF574_RS30620 1377..1505 - 129 WP_000523570.1 hypothetical protein -
HF574_RS28440 (HF574_29175) 1668..1892 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
HF574_RS28445 (HF574_29180) 1876..2142 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF574_RS28450 (HF574_29185) 2212..2562 - 351 WP_004197756.1 hypothetical protein -
HF574_RS28455 (HF574_29190) 2628..3173 - 546 WP_216833410.1 hypothetical protein -
HF574_RS28460 (HF574_29195) 3199..3525 - 327 WP_050516389.1 hypothetical protein -
HF574_RS28465 (HF574_29200) 4681..4857 + 177 WP_004197757.1 hypothetical protein -
HF574_RS28470 (HF574_29205) 4847..5191 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T205950 WP_004197762.1 NZ_CP076552:1876-2142 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T205950 NZ_CP101937:c2199059-2198883 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT205950 WP_000879771.1 NZ_CP076552:1668-1892 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT205950 NZ_CP101937:2199000-2199100 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCATTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References