Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4765159..4765675 Replicon chromosome
Accession NZ_CP076518
Organism Klebsiella pneumoniae strain K186

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KNW01_RS23445 Protein ID WP_002886902.1
Coordinates 4765159..4765443 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KNW01_RS23450 Protein ID WP_002886901.1
Coordinates 4765433..4765675 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNW01_RS23420 (KNW01_23420) 4760643..4760906 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KNW01_RS23425 (KNW01_23425) 4761036..4761209 + 174 WP_002886906.1 hypothetical protein -
KNW01_RS23430 (KNW01_23430) 4761212..4761955 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KNW01_RS23435 (KNW01_23435) 4762312..4764450 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KNW01_RS23440 (KNW01_23440) 4764691..4765155 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KNW01_RS23445 (KNW01_23445) 4765159..4765443 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KNW01_RS23450 (KNW01_23450) 4765433..4765675 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KNW01_RS23455 (KNW01_23455) 4765753..4767663 - 1911 WP_004152270.1 PRD domain-containing protein -
KNW01_RS23460 (KNW01_23460) 4767686..4768840 - 1155 WP_002886900.1 lactonase family protein -
KNW01_RS23465 (KNW01_23465) 4768906..4769646 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T205904 WP_002886902.1 NZ_CP076518:c4765443-4765159 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T205904 NZ_CP101922:3369944-3370162 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT205904 WP_002886901.1 NZ_CP076518:c4765675-4765433 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT205904 NZ_CP101922:3369544-3369918 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References