Detailed information of TA system TA020561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3783314..3783999
• Replicon: chromosome
• Accession: NC_002945
• Organism: Mycobacterium bovis AF2122/97

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: BQ2027_RS17565
• Protein ID: WP_003417998.1
• Coordinates: 3783589..3783999 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BQ2027_RS17560
• Protein ID: WP_003912220.1
• Coordinates: 3783314..3783592 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BQ2027_RS17540 (BQ2027_MB3437C)	3779303..3780904	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
BQ2027_RS17545 (BQ2027_MB3438C)	3780921..3781625	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
BQ2027_RS17550 (BQ2027_MB3439C)	3781743..3782309	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
BQ2027_RS17555 (BQ2027_MB3440)	3782371..3783258	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
BQ2027_RS17560 (BQ2027_MB3441)	3783314..3783592	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BQ2027_RS17565 (BQ2027_MB3442)	3783589..3783999	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
BQ2027_RS17570 (BQ2027_MB3443C)	3784032..3785768	-	1737	WP_003418002.1	cholesterol oxidase	-
BQ2027_RS17575 (BQ2027_MB3444C)	3785824..3786951	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
BQ2027_RS17580 (BQ2027_MB3445C)	3786971..3788560	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T20561 WP_003417998.1 NC_002945:3783589-3783999 [Mycobacterium tuberculosis variant bovis AF2122/97]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T20561 NC_002945:3783589-3783999 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT20561 WP_003912220.1 NC_002945:3783314-3783592 [Mycobacterium tuberculosis variant bovis AF2122/97]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT20561 NC_002945:3783314-3783592 [Mycobacterium tuberculosis variant bovis AF2122/97]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Structures

Toxin

• AlphaFold DB: G0TIR9