Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/ParD(antitoxin) |
| Location | 2895028..2896020 | Replicon | chromosome |
| Accession | NZ_CP076378 | ||
| Organism | Mycobacterium intracellulare strain S2-8 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | KN249_RS13895 | Protein ID | WP_009956379.1 |
| Coordinates | 2895028..2895606 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A7I7TS83 |
| Locus tag | KN249_RS13900 | Protein ID | WP_009956380.1 |
| Coordinates | 2895631..2896020 (-) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KN249_RS13870 (KN249_13835) | 2890986..2891957 | - | 972 | WP_029385267.1 | sigma-70 family RNA polymerase sigma factor | - |
| KN249_RS13875 (KN249_13840) | 2892123..2892473 | + | 351 | WP_009956374.1 | DoxX family protein | - |
| KN249_RS13880 (KN249_13845) | 2892485..2893285 | - | 801 | WP_009956375.1 | nuclear transport factor 2 family protein | - |
| KN249_RS13885 (KN249_13850) | 2893285..2893845 | - | 561 | WP_029385272.1 | pyrazinamidase PncA | - |
| KN249_RS13890 (KN249_13855) | 2893941..2895008 | + | 1068 | WP_036397470.1 | DoxX family protein | - |
| KN249_RS13895 (KN249_13860) | 2895028..2895606 | - | 579 | WP_009956379.1 | zeta toxin family protein | Toxin |
| KN249_RS13900 (KN249_13865) | 2895631..2896020 | - | 390 | WP_009956380.1 | hypothetical protein | Antitoxin |
| KN249_RS13905 (KN249_13870) | 2896078..2896365 | - | 288 | WP_225332075.1 | hypothetical protein | - |
| KN249_RS13910 (KN249_13875) | 2896393..2897352 | - | 960 | WP_225331100.1 | SAM-dependent methyltransferase | - |
| KN249_RS13915 (KN249_13880) | 2897388..2897999 | + | 612 | WP_009956383.1 | TetR/AcrR family transcriptional regulator | - |
| KN249_RS13920 (KN249_13885) | 2898023..2898568 | - | 546 | WP_044059213.1 | gluconokinase | - |
| KN249_RS13925 (KN249_13890) | 2898565..2900568 | - | 2004 | WP_009956386.1 | phosphotransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 20962.05 Da Isoelectric Point: 11.0233
>T205580 WP_009956379.1 NZ_CP076378:c2895606-2895028 [Mycobacterium intracellulare]
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD
MQRLDLVVGPNGAGKSTFIAFTLAPLLPGSPVVNADEIARQRWPGEAAGRAYDAAQIAAATRAKLIDLGRSFIAETVFSH
PSKLDLVRTAHRAGFTAVLHAMLIPEDLAVERVRHRVRAGGHDVPETKVRERHRRLWTPVTDAIALSDVATVYDSGRLRG
PRIVARLSGGMTIGSPDWPAWAPEILRSRWPD
Download Length: 579 bp
>T205580 NZ_CP076378:c2895606-2895028 [Mycobacterium intracellulare]
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
ATGCAGCGACTTGACCTGGTAGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACGCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGATGAGATCGCAAGGCAGCGCTGGCCGGGGGAGGCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGCCACGCGCGCGAAGTTGATCGACCTGGGGCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCGTCCGCACCGCCCACCGAGCGGGCTTCACCGCCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTCCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTCTCCGACGTCGCCACCGTCTACGACAGCGGCCGGCTGCGCGGG
CCGCGCATTGTCGCCCGCCTCAGCGGCGGCATGACGATCGGTTCACCGGACTGGCCGGCGTGGGCTCCGGAGATCTTGCG
GTCGCGCTGGCCGGACTAG
Antitoxin
Download Length: 130 a.a. Molecular weight: 13512.89 Da Isoelectric Point: 5.1828
>AT205580 WP_009956380.1 NZ_CP076378:c2896020-2895631 [Mycobacterium intracellulare]
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
MADAPDRVTRVASDLMDSAASEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGQLATGELTVEEGVVFNAEI
SAAIEESLVHADYGATLAGHGVTTVALNEDGDIVEHRPDGAAVVLARGR
Download Length: 390 bp
>AT205580 NZ_CP076378:c2896020-2895631 [Mycobacterium intracellulare]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGGCGGC
GGGTCGAGGCCGCGCTGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCCGCCATCGAAGAAAGCCTGGTGCACGCCGACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|