Detailed information of TA system TA205568

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 477460..477665
• Replicon: chromosome
• Accession: NZ_CP076377
• Organism: Clostridioides difficile strain S-0352

Toxin (Protein)

• Gene name: CD1233.1
• Uniprot ID: A0A069A9H6
• Locus tag: KNZ78_RS02370
• Protein ID: WP_009896140.1
• Coordinates: 477460..477612 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	SQ808
Locus tag	-
Coordinates	477592..477665 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNZ78_RS02350 (473400)	473400..473684	-	285	WP_003419254.1	sigma-70 family RNA polymerase sigma factor	-
KNZ78_RS02355 (473707)	473707..475224	-	1518	WP_003438169.1	recombinase family protein	-
KNZ78_RS02360 (475349)	475349..476170	-	822	WP_003438170.1	tetratricopeptide repeat protein	-
KNZ78_RS02365 (476361)	476361..477388	+	1028	Protein_464	cell wall-binding protein Cwp26	-
KNZ78_RS02370 (477460)	477460..477612	+	153	WP_009896140.1	hypothetical protein	Toxin
- (477592)	477592..477665	-	74	NuclAT_13	-	Antitoxin
- (477592)	477592..477665	-	74	NuclAT_8	-	Antitoxin
- (477592)	477592..477665	-	74	NuclAT_8	-	Antitoxin
KNZ78_RS02375 (479306)	479306..479530	-	225	WP_021367699.1	helix-turn-helix transcriptional regulator	-
KNZ78_RS02380 (480209)	480209..480364	+	156	WP_021363414.1	hypothetical protein	-
KNZ78_RS02385 (480643)	480643..480861	+	219	WP_009889000.1	hypothetical protein	-
KNZ78_RS02390 (481518)	481518..481712	+	195	WP_021367700.1	hypothetical protein	-
KNZ78_RS02395 (482081)	482081..482464	-	384	WP_003433385.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5811.96 Da
• Isoelectric Point: 11.1039

>T205568 WP_009896140.1 NZ_CP076377:477460-477612 [Clostridioides difficile]
MDNFLFNVLASLTASVVVYLISKLFKKAKSHSRTKSDLRVEFKFIFKSKK

Nucleotide

• Length: 153 bp

>T205568 NZ_CP101752:c143379-143098 [Pseudomonas citronellolis]
ATGAGCCTGCAGTGGACGCACAAGGCGGCCGCCGACCTGGACGGCCTGTACGACCACTACGTGGTGCTGATCGGCCCGGA
GAAGGCGCTGAAGGCCATCCAGGACGTGGTCGGCCAGGTGAAGGCGCTGGCCGACCTAAGCCTGAGCAGCGTCGGCCGGC
CCAGCGAGGTGCCCGGCGTACGCGAATTGCCGCTGGAACGCTGGCCTTACCAGGCCGCCTACCGGGTGAAAGGCCGCGAT
GTACAAATTTTGCGCATCGATTCTGTGGATAACCCGGGGTAA

Antitoxin

Nucleotide

• Length: 74 bp

>AT205568 NZ_CP076377:c477665-477592 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTTGCGTTAGAGTGGAGTTCATCATAAACAGAGTTTATTTTTTGGATTTAAATAT

Structures

Toxin

• AlphaFold DB: A0A069A9H6

Antitoxin