Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN_Sll0205-like-Phd |
| Location | 3097603..3098207 | Replicon | chromosome |
| Accession | NC_002945 | ||
| Organism | Mycobacterium bovis AF2122/97 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P71623 |
| Locus tag | BQ2027_RS14545 | Protein ID | WP_003414492.1 |
| Coordinates | 3097603..3097995 (-) | Length | 131 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A829CBY8 |
| Locus tag | BQ2027_RS14550 | Protein ID | WP_003414495.1 |
| Coordinates | 3097992..3098207 (-) | Length | 72 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BQ2027_RS14515 (BQ2027_MB2848C) | 3092753..3093541 | - | 789 | WP_193692467.1 | CRISPR-associated endoribonuclease Cas6 | - |
| BQ2027_RS14520 (BQ2027_MB2849C) | 3093875..3094420 | - | 546 | WP_003904931.1 | DUF1802 family protein | - |
| BQ2027_RS14525 (BQ2027_MB2850C) | 3094692..3095576 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| BQ2027_RS14530 (BQ2027_MB2851C) | 3095579..3096466 | - | 888 | WP_003414414.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
| BQ2027_RS14535 (BQ2027_MB2852C) | 3096771..3097316 | - | 546 | WP_010950781.1 | DUF1802 family protein | - |
| BQ2027_RS14540 (BQ2027_MB2852A) | 3097313..3097582 | - | 270 | WP_003414489.1 | DUF2277 family protein | - |
| BQ2027_RS14545 (BQ2027_MB2853C) | 3097603..3097995 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| BQ2027_RS14550 (BQ2027_MB2854C) | 3097992..3098207 | - | 216 | WP_003414495.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| BQ2027_RS14555 (BQ2027_MB2855) | 3098254..3099003 | + | 750 | WP_010950782.1 | enoyl-CoA hydratase | - |
| BQ2027_RS14560 (BQ2027_MB2856C) | 3099082..3100164 | - | 1083 | WP_003414499.1 | sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC | - |
| BQ2027_RS14565 (BQ2027_MB2857C) | 3100157..3101467 | - | 1311 | WP_010950783.1 | ABC transporter substrate-binding protein | - |
| BQ2027_RS14570 (BQ2027_MB2858C) | 3101470..3102297 | - | 828 | WP_003414504.1 | carbohydrate ABC transporter permease | - |
| BQ2027_RS14575 | 3102294..3103204 | - | 911 | Protein_2913 | sugar ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 131 a.a. Molecular weight: 14610.74 Da Isoelectric Point: 6.7594
>T20554 WP_003414492.1 NC_002945:c3097995-3097603 [Mycobacterium tuberculosis variant bovis AF2122/97]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW
Download Length: 393 bp
>T20554 NC_002945:c3097995-3097603 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG
Antitoxin
Download Length: 72 a.a. Molecular weight: 7511.55 Da Isoelectric Point: 4.9732
>AT20554 WP_003414495.1 NC_002945:c3098207-3097992 [Mycobacterium tuberculosis variant bovis AF2122/97]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS
Download Length: 216 bp
>AT20554 NC_002945:c3098207-3097992 [Mycobacterium tuberculosis variant bovis AF2122/97]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BWM8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CBY8 |