Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3959845..3960431 Replicon chromosome
Accession NZ_CP076274
Organism Escherichia coli strain P393-F10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag A7A10_RS19675 Protein ID WP_042014162.1
Coordinates 3960201..3960431 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag A7A10_RS19670 Protein ID WP_000593555.1
Coordinates 3959845..3960204 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A10_RS19645 (3955977) 3955977..3956921 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
A7A10_RS19650 (3956918) 3956918..3957751 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
A7A10_RS19655 (3957751) 3957751..3958515 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
A7A10_RS19660 (3958512) 3958512..3959318 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
A7A10_RS19665 (3959324) 3959324..3959725 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
A7A10_RS19670 (3959845) 3959845..3960204 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7A10_RS19675 (3960201) 3960201..3960431 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
A7A10_RS19680 (3960535) 3960535..3961659 - 1125 WP_001314210.1 ABC transporter permease -
A7A10_RS19685 (3961659) 3961659..3964394 - 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T205243 WP_042014162.1 NZ_CP076274:c3960431-3960201 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T205243 NZ_CP101519:735209-735502 [Ensifer adhaerens]
ATGGCGTTTCGGCTTTCCGTCGCGGCAGAAGAAGACATCATCGCGATCGCCGCAGATGGGGTGCGCCTTTTCGGCTCCGC
CCAGGCGCGGCGATATCACGATGAACTCTTCGCCGTATTCGCCTTGATTGCCGCCAACCCGCGCATGGCGCGCGAACGCA
CGGAGCTGTCGCCGCCGATGCGCATCCATCCGTTCAAGGCGCATCTGGTCGTCTACCGGGTCGAGGCGGACGGCGACATC
CTCGTCGTTCGCGTCCGTCATGGGCATGAGGACTGGATCAGCAACGCATTTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT205243 WP_000593555.1 NZ_CP076274:c3960204-3959845 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT205243 NZ_CP101519:734961-735209 [Ensifer adhaerens]
ATGGCGACGATGAACGTATCCTTGCCCGACCCGATGAAGGATTGGGTGGAAGCGCAAACGCGCACGGGCCGTTATGCCAA
CGCCAGCGATTATGTGCGCGACCTCATCCGCAGGGATCAGGAGCGAAATGACAAGGTTGCGGTGATGCAACGCTTTGTCG
ACGACGGTCTGAAGAGCGGCGTCGGGTCCCGCTCCAAGGACGAGCTCTTTTCCGCGGCGCTTACGCGCGCTGAAGTGCCG
CGCGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References