Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3933727..3934313 Replicon chromosome
Accession NZ_CP076272
Organism Escherichia coli strain E21845/O/A

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag A7A11_RS19485 Protein ID WP_042014162.1
Coordinates 3934083..3934313 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag A7A11_RS19480 Protein ID WP_000593555.1
Coordinates 3933727..3934086 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A11_RS19455 (3929859) 3929859..3930803 + 945 WP_032254808.1 nickel ABC transporter permease subunit NikB -
A7A11_RS19460 (3930800) 3930800..3931633 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
A7A11_RS19465 (3931633) 3931633..3932397 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
A7A11_RS19470 (3932394) 3932394..3933200 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
A7A11_RS19475 (3933206) 3933206..3933607 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
A7A11_RS19480 (3933727) 3933727..3934086 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A7A11_RS19485 (3934083) 3934083..3934313 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
A7A11_RS19490 (3934417) 3934417..3935541 - 1125 WP_001314210.1 ABC transporter permease -
A7A11_RS19495 (3935541) 3935541..3938276 - 2736 WP_113441165.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T205209 WP_042014162.1 NZ_CP076272:c3934313-3934083 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T205209 NZ_CP101497:206059-206319 [Microcella sp. MMS21-STM10]
ATGAGTCGCACCGTCGCCTTCGATCCGCACGGGTGGGAGGACTACGTCTACTGGCAGTCCCAAGATCGCAAGACGCTCAA
GCGCATCAATCTGCTCATCACCGACGCTCTGCGTGACCCGTTCGCGGGCATCGGCAAGCCAGAGCCGCTCAAGCACATCC
TGTCGGGCGCGTGGTCACGGCGCGTCGACGACGTGAACCGCCTCGTCTACTTCGTGACCGACGACCACATCGTGATCCTG
CAGGCCCGCCAGCACTACTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT205209 WP_000593555.1 NZ_CP076272:c3934086-3933727 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT205209 NZ_CP101497:205794-206045 [Microcella sp. MMS21-STM10]
ATGACTGCCATTAGCGCCACCGAAGCGCGTAAGACGCTCTTCGGGCTCATCCAGCAGGTCAACGACGACCACACCGCGGT
GGAGGTCGTCTCCAAGCACGGCAACGCGGTCATTCTCTCAAAGGCCGACTACGACGCCATGACCGAGACGGCGTACCTGC
TGCGCAACCCGGCGAGCGCCGAGCGACTGCTCGCCTCGATCGAGCGCGCGCGCCGTGGAGAGTTCGAGCAGCACACCCTC
ACCGACGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References