Detailed information of TA system TA205194

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1763502..1765090
• Replicon: chromosome
• Accession: NZ_CP076272
• Organism: Escherichia coli strain E21845/O/A

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: A7A11_RS08710
• Protein ID: WP_001125463.1
• Coordinates: 1763502..1764824 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: A7A11_RS08715
• Protein ID: WP_001296726.1
• Coordinates: 1764824..1765090 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A11_RS08695 (1760914)	1760914..1761624	-	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-
A7A11_RS08700 (1761985)	1761985..1762548	-	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
A7A11_RS08705 (1762982)	1762982..1763190	-	209	Protein_1707	AraC family transcriptional regulator	-
A7A11_RS08710 (1763502)	1763502..1764824	-	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
A7A11_RS08715 (1764824)	1764824..1765090	-	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T205194 WP_001125463.1 NZ_CP076272:c1764824-1763502 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T205194 NZ_CP101417:3820972-3821256 [Xanthomonas hortorum]
ATGATCCAGTCGTTTCGATGCAAGCACACACGCGCCTTGTTCGAAGGCGCTAGCCCGCGGCAATTCCGGTCCATGCAGGC
AGCGGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAATCGGCTTG
AGCTGTTGGCGGGTACGCGTGCAGGTCAGCACAGCATCAGCATCAGCATCAATGACCAATGGCGTGTGTGCTTTGTCTGG
ACTGACGCCGGCCCCGAGCACGTTGAGATTGTTGATTACCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT205194 WP_001296726.1 NZ_CP076272:c1765090-1764824 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT205194 NZ_CP101417:3821266-3821565 [Xanthomonas hortorum]
ATGCGACTCACCAACAAACTGCGCGCCATCCATCCTGGCGAAATCCTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATCAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCAGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTGCAGGCCACGTATGAACTC
AAGACCTTGCCCAACCGCAGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0