Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 547403..548021 Replicon chromosome
Accession NZ_CP076272
Organism Escherichia coli strain E21845/O/A

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag A7A11_RS02570 Protein ID WP_001291435.1
Coordinates 547403..547621 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag A7A11_RS02575 Protein ID WP_000344800.1
Coordinates 547647..548021 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7A11_RS02535 (542692) 542692..543264 + 573 WP_115427225.1 YbaY family lipoprotein -
A7A11_RS02540 (543295) 543295..543606 - 312 WP_000409911.1 MGMT family protein -
A7A11_RS02550 (543985) 543985..544338 + 354 WP_000878141.1 DUF1428 family protein -
A7A11_RS02555 (544380) 544380..545930 - 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
A7A11_RS02560 (546094) 546094..546564 - 471 WP_000136192.1 YlaC family protein -
A7A11_RS02565 (546680) 546680..547231 - 552 WP_000102564.1 maltose O-acetyltransferase -
A7A11_RS02570 (547403) 547403..547621 - 219 WP_001291435.1 HHA domain-containing protein Toxin
A7A11_RS02575 (547647) 547647..548021 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
A7A11_RS02580 (548567) 548567..551716 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
A7A11_RS02585 (551739) 551739..552932 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T205188 WP_001291435.1 NZ_CP076272:c547621-547403 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T205188 NZ_CP101417:1506648-1506929 [Xanthomonas hortorum]
ATGATCAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGCAGGGCGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GCCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTACGCATTCCGCCTGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAATGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT205188 WP_000344800.1 NZ_CP076272:c548021-547647 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT205188 NZ_CP101417:1506947-1507237 [Xanthomonas hortorum]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATTCTGCTCGAAGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCTACTGATGTACCGCCGCGCCGCATCAATGAGATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCCGCATTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGATTACGAGCTGGAACAAGCC
CATCGCGCGCTGGGCGATCTGCCGTCACGGATCAAGCGGCTGGCTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References