Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 36602..36856 | Replicon | plasmid pCeylon31IncF |
| Accession | NZ_CP076271 | ||
| Organism | Escherichia coli strain Ceylon31 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | Q0H0B2 |
| Locus tag | A7A14_RS23905 | Protein ID | WP_001300273.1 |
| Coordinates | 36602..36751 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 36795..36856 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A7A14_RS23875 (32747) | 32747..32902 | + | 156 | Protein_29 | IS110 family transposase | - |
| A7A14_RS23880 (33298) | 33298..33549 | - | 252 | WP_071889275.1 | HTH domain-containing protein | - |
| A7A14_RS23885 (34899) | 34899..35756 | - | 858 | WP_000131011.1 | incFII family plasmid replication initiator RepA | - |
| A7A14_RS23890 (35749) | 35749..35823 | - | 75 | WP_001365705.1 | RepA leader peptide Tap | - |
| A7A14_RS23895 (35872) | 35872..35997 | + | 126 | WP_094259391.1 | replication protein RepA | - |
| A7A14_RS23900 (36070) | 36070..36318 | - | 249 | WP_000083838.1 | replication regulatory protein RepA | - |
| A7A14_RS23905 (36602) | 36602..36751 | - | 150 | WP_001300273.1 | Hok/Gef family protein | Toxin |
| - (36795) | 36795..36856 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (36795) | 36795..36856 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (36795) | 36795..36856 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (36795) | 36795..36856 | + | 62 | NuclAT_1 | - | Antitoxin |
| A7A14_RS23910 (37031) | 37031..37165 | - | 135 | WP_001058542.1 | hypothetical protein | - |
| A7A14_RS23915 (37516) | 37516..37977 | - | 462 | WP_000760078.1 | thermonuclease family protein | - |
| A7A14_RS23920 (38720) | 38720..38923 | - | 204 | WP_040073114.1 | hypothetical protein | - |
| A7A14_RS23925 (39078) | 39078..39635 | - | 558 | WP_000139319.1 | fertility inhibition protein FinO | - |
| A7A14_RS23930 (39738) | 39738..40598 | - | 861 | WP_000704529.1 | alpha/beta hydrolase | - |
| A7A14_RS23935 (40657) | 40657..41397 | - | 741 | WP_094259392.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | pefD / pefC / pefA | 1..127140 | 127140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5554.72 Da Isoelectric Point: 8.7678
>T205178 WP_001300273.1 NZ_CP076271:c36751-36602 [Escherichia coli]
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGVLAVCATVLCFLLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T205178 NZ_CP101397:7020292-7020543 [Streptomyces cavourensis]
ATGCGCACGATGACCTACACCGAGTCGCGGGCGAAGTACGCGGAAACCCTGAGCGCGGTCGTGGACGACCGCGAGGAGGT
CGTGGTCACGCGGGCCGGCCATGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCGCTCAAGGAGACCGCGTACC
AGCTCCGCAGCCCGGAGAACGCCCGTCGGCTGCTGGCCTCGATCGAGCGCCTGGAGAGCGGGGGCGGCACGGTGCGGGAG
CTGGCGGAGTGA
ATGCGCACGATGACCTACACCGAGTCGCGGGCGAAGTACGCGGAAACCCTGAGCGCGGTCGTGGACGACCGCGAGGAGGT
CGTGGTCACGCGGGCCGGCCATGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCGCTCAAGGAGACCGCGTACC
AGCTCCGCAGCCCGGAGAACGCCCGTCGGCTGCTGGCCTCGATCGAGCGCCTGGAGAGCGGGGGCGGCACGGTGCGGGAG
CTGGCGGAGTGA
Antitoxin
Download Length: 62 bp
>AT205178 NZ_CP076271:36795-36856 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
