Detailed information of TA system TA205058

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1505902..1506273
• Replicon: chromosome
• Accession: NZ_CP076262
• Organism: Escherichia coli strain 0-4

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A4Z0JXD0
• Locus tag: A7A18_RS07290
• Protein ID: WP_001406909.1
• Coordinates: 1506079..1506273 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1505902..1506080 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7A18_RS07265 (1501857)	1501857..1503230	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
A7A18_RS07270 (1503359)	1503359..1504294	-	936	WP_001157377.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
A7A18_RS07275 (1504346)	1504346..1505581	-	1236	WP_000040843.1	site-specific integrase	-
A7A18_RS07280 (1505583)	1505583..1505798	-	216	WP_000079604.1	excisionase XisR	-
- (1505902)	1505902..1506080	+	179	NuclAT_0	-	Antitoxin
- (1505902)	1505902..1506080	+	179	NuclAT_0	-	Antitoxin
- (1505902)	1505902..1506080	+	179	NuclAT_0	-	Antitoxin
- (1505902)	1505902..1506080	+	179	NuclAT_0	-	Antitoxin
A7A18_RS07285 (1505898)	1505898..1506086	-	189	WP_001406908.1	DUF1187 family protein	-
A7A18_RS07290 (1506079)	1506079..1506273	-	195	WP_001406909.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
A7A18_RS07295 (1506336)	1506336..1507388	-	1053	WP_001406910.1	RecT family recombinase	-
A7A18_RS07300 (1507400)	1507400..1510522	-	3123	WP_096974680.1	exodeoxyribonuclease VIII	-
A7A18_RS07305 (1510624)	1510624..1510899	-	276	WP_032218014.1	hypothetical protein	-
A7A18_RS07310 (1510974)	1510974..1511150	-	177	WP_032218016.1	YdaE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1504346..1555017	50671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7001.00 Da
• Isoelectric Point: 9.6161

>T205058 WP_001406909.1 NZ_CP076262:c1506273-1506079 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKGISGYYRVKCNGCESRSGYGGSEKAALERWNKRTIGNNNGGVHV

Nucleotide

• Length: 195 bp

>T205058 NZ_CP101373:3758642-3758917 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT205058 NZ_CP076262:1505902-1506080 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCACATTCTGATTTGGTTAGTTTTGTTTTTGAGTATCTTGTCCAGTTGGTAGGCGAACCGCCTTCCTTTT
CAATAGTGGCAGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A4Z0JXD0

Antitoxin