Detailed information of TA system TA204988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 2278050..2278720
• Replicon: chromosome
• Accession: NZ_CP076248
• Organism: Xanthomonas translucens pv. hordei strain UPB947

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KFS83_RS09830
• Protein ID: WP_058361064.1
• Coordinates: 2278301..2278720 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2S7EM03
• Locus tag: KFS83_RS09825
• Protein ID: WP_003473422.1
• Coordinates: 2278050..2278304 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFS83_RS09805 (KFS83_09755)	2273587..2274552	-	966	WP_065898826.1	IS1595 family transposase	-
KFS83_RS09810 (KFS83_09760)	2275069..2276204	+	1136	WP_153476785.1	IS3 family transposase	-
KFS83_RS09815 (KFS83_09765)	2276240..2276740	+	501	Protein_1920	replication protein C, IncQ-type	-
KFS83_RS09820 (KFS83_09770)	2277357..2277638	+	282	WP_058361065.1	TraK family protein	-
KFS83_RS09825 (KFS83_09775)	2278050..2278304	+	255	WP_003473422.1	hypothetical protein	Antitoxin
KFS83_RS09830 (KFS83_09780)	2278301..2278720	+	420	WP_058361064.1	type II toxin-antitoxin system VapC family toxin	Toxin
KFS83_RS09835 (KFS83_09785)	2278877..2279647	+	771	WP_058361066.1	P-type conjugative transfer protein TrbJ	-
KFS83_RS09840 (KFS83_09790)	2279658..2279816	+	159	WP_153476784.1	hypothetical protein	-
KFS83_RS09845 (KFS83_09795)	2279818..2281218	+	1401	WP_058361063.1	P-type conjugative transfer protein TrbL	-
KFS83_RS09850 (KFS83_09800)	2281332..2281574	+	243	WP_033981742.1	type I toxin-antitoxin system ptaRNA1 family toxin	-
KFS83_RS09855 (KFS83_09805)	2281586..2281870	+	285	WP_058361062.1	hypothetical protein	-
KFS83_RS09860 (KFS83_09810)	2281873..2282241	+	369	WP_058361061.1	conjugal transfer transcriptional regulator TraJ	-
KFS83_RS09865 (KFS83_09815)	2282209..2282598	-	390	Protein_1930	replication protein C, IncQ-type	-
KFS83_RS09870 (KFS83_09820)	2282570..2283448	-	879	WP_058361060.1	helicase RepA family protein	-
KFS83_RS09875 (KFS83_09825)	2283452..2283685	-	234	WP_003472509.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2273131..2292853	19722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14945.19 Da
• Isoelectric Point: 4.9167

>T204988 WP_058361064.1 NZ_CP076248:2278301-2278720 [Xanthomonas translucens pv. hordei]
MIVLDTNVVSEAMKPEPDPAVRAWLNEQVAETLYLSSVTLAELLFGIGALPNGKRKKGLGEALDGLLELFSERVLMFDTE
AARNYAELAVKARIAGKGFPTPDGYIGAIAASKGFIVATRDTSPFEAAGLTVINPWNHR

Nucleotide

• Length: 420 bp

>T204988 NZ_CP101310:2164338-2164441 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9507.88 Da
• Isoelectric Point: 7.2071

>AT204988 WP_003473422.1 NZ_CP076248:2278050-2278304 [Xanthomonas translucens pv. hordei]
MAILTVRNVPDEVHRALRLRAAEHGRSTEAEVREILESAVKSQKRIRMGDALAELGRRVGLTNDDFAVLDQVRDKVPAEP
MRFE

Nucleotide

• Length: 255 bp

>AT204988 NZ_CP101310:c2164479-2164211 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Structures

Antitoxin

• AlphaFold DB: A0A2S7EM03