Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-sokW/Ldr(toxin)
Location 283113..283334 Replicon chromosome
Accession NZ_CP076237
Organism Escherichia coli O157:H7 strain 146N4

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag JKN67_RS01365 Protein ID WP_001295224.1
Coordinates 283227..283334 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 283113..283178 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKN67_RS01345 (278553) 278553..279455 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
JKN67_RS01350 (279466) 279466..280449 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
JKN67_RS01355 (280446) 280446..281450 + 1005 WP_000107027.1 dipeptide ABC transporter ATP-binding subunit DppF -
JKN67_RS01360 (281480) 281480..282751 - 1272 WP_001301684.1 aromatic amino acid transport family protein -
- (283113) 283113..283178 - 66 NuclAT_16 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_16 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_16 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_16 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_21 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_21 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_21 - Antitoxin
- (283113) 283113..283178 - 66 NuclAT_21 - Antitoxin
JKN67_RS01365 (283227) 283227..283334 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
JKN67_RS01370 (283421) 283421..285100 - 1680 WP_000191596.1 cellulose biosynthesis protein BcsG -
JKN67_RS01375 (285097) 285097..285288 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
JKN67_RS01380 (285285) 285285..286856 - 1572 WP_001204920.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
JKN67_RS01385 (287129) 287129..287317 + 189 WP_001063316.1 cellulose biosynthesis protein BcsR -
JKN67_RS01390 (287329) 287329..288081 + 753 Protein_275 cellulose biosynthesis protein BcsQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T204862 WP_001295224.1 NZ_CP076237:283227-283334 [Escherichia coli O157:H7]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T204862 NZ_CP101269:c4327394-4327221 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACTTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 66 bp

>AT204862 NZ_CP076237:c283178-283113 [Escherichia coli O157:H7]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References