Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3264261..3265056 | Replicon | chromosome |
| Accession | NZ_CP076235 | ||
| Organism | Escherichia coli O157:H7 strain 9.1_Anguil | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | JKN68_RS16870 | Protein ID | WP_000854914.1 |
| Coordinates | 3264261..3264635 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0B0VS41 |
| Locus tag | JKN68_RS16875 | Protein ID | WP_001280954.1 |
| Coordinates | 3264682..3265056 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKN68_RS16830 (3259265) | 3259265..3259756 | - | 492 | WP_001301587.1 | DUF1097 domain-containing protein | - |
| JKN68_RS16835 (3259858) | 3259858..3260412 | - | 555 | WP_001001917.1 | molecular chaperone YcdY | - |
| JKN68_RS16840 (3260436) | 3260436..3261173 | - | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| JKN68_RS16845 (3261228) | 3261228..3262166 | - | 939 | WP_000351284.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| JKN68_RS16855 (3262637) | 3262637..3263479 | - | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| JKN68_RS16860 (3263564) | 3263564..3263761 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| JKN68_RS16865 (3263773) | 3263773..3264264 | - | 492 | WP_000976853.1 | DUF5983 family protein | - |
| JKN68_RS16870 (3264261) | 3264261..3264635 | - | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| JKN68_RS16875 (3264682) | 3264682..3265056 | - | 375 | WP_001280954.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| JKN68_RS16880 (3265219) | 3265219..3265440 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| JKN68_RS16885 (3265503) | 3265503..3265979 | - | 477 | WP_001186738.1 | RadC family protein | - |
| JKN68_RS16890 (3265995) | 3265995..3266480 | - | 486 | WP_000214398.1 | antirestriction protein | - |
| JKN68_RS16895 (3266571) | 3266571..3267389 | - | 819 | WP_001234682.1 | DUF932 domain-containing protein | - |
| JKN68_RS16900 (3267729) | 3267729..3268799 | - | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| JKN68_RS16905 (3268796) | 3268796..3269701 | - | 906 | WP_000203541.1 | diguanylate cyclase regulator RdcB family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Genomic island | - | csgB / csgD / csgE / csgF / csgG | 3255647..3266480 | 10833 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T204849 WP_000854914.1 NZ_CP076235:c3264635-3264261 [Escherichia coli O157:H7]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T204849 NZ_CP101269:1849280-1849534 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13718.51 Da Isoelectric Point: 6.6249
>AT204849 WP_001280954.1 NZ_CP076235:c3265056-3264682 [Escherichia coli O157:H7]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT204849 NZ_CP101269:1849032-1849283 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B0VS41 |