Detailed information of TA system TA204805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2495099..2495577
• Replicon: chromosome
• Accession: NZ_CP076232
• Organism: Escherichia coli O157:H7 strain 7.1_Anguil

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: XE90_RS11740
• Protein ID: WP_001303876.1
• Coordinates: 2495099..2495386 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: XE90_RS11745
• Protein ID: WP_000536233.1
• Coordinates: 2495386..2495577 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XE90_RS11710 (2490246)	2490246..2492717	-	2472	WP_000034474.1	exonuclease	-
XE90_RS11715 (2492811)	2492811..2493002	-	192	WP_001098307.1	DUF1482 family protein	-
XE90_RS11720 (2492999)	2492999..2493187	-	189	WP_000413705.1	cell division inhibition protein DicB	-
XE90_RS11725 (2493763)	2493763..2493948	+	186	WP_001133046.1	hypothetical protein	-
XE90_RS11730 (2494135)	2494135..2494524	-	390	WP_000394511.1	hypothetical protein	-
XE90_RS29130 (2494536)	2494536..2494664	-	129	WP_000344963.1	protein YdfB	-
XE90_RS11735 (2494666)	2494666..2494821	-	156	WP_000379575.1	DUF1391 family protein	-
XE90_RS11740 (2495099)	2495099..2495386	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XE90_RS11745 (2495386)	2495386..2495577	-	192	WP_000536233.1	hypothetical protein	Antitoxin
XE90_RS11750 (2495605)	2495605..2496006	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
XE90_RS11755 (2496115)	2496115..2496387	+	273	WP_000887453.1	YdaS family helix-turn-helix protein	-
XE90_RS11760 (2496371)	2496371..2496796	+	426	WP_000693855.1	toxin YdaT family protein	-
XE90_RS11765 (2497003)	2497003..2497458	-	456	WP_000273724.1	hypothetical protein	-
XE90_RS11770 (2497537)	2497537..2498628	+	1092	WP_001205823.1	hypothetical protein	-
XE90_RS11775 (2498635)	2498635..2499381	+	747	WP_000788751.1	ATP-binding protein	-
XE90_RS11780 (2499403)	2499403..2500173	+	771	WP_226326702.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T204805 WP_001303876.1 NZ_CP076232:c2495386-2495099 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T204805 NZ_CP101257:742829-743125 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT204805 WP_000536233.1 NZ_CP076232:c2495577-2495386 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT204805 NZ_CP101257:743127-743522 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA