Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3620820..3621298 Replicon chromosome
Accession NZ_CP076230
Organism Escherichia coli O157:H7 strain Rafaela_II

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag XF37_RS18855 Protein ID WP_001303876.1
Coordinates 3621011..3621298 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag XF37_RS18850 Protein ID WP_000536233.1
Coordinates 3620820..3621011 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XF37_RS18815 (3616224) 3616224..3616994 - 771 WP_000450992.1 DUF1627 domain-containing protein -
XF37_RS18820 (3617016) 3617016..3617762 - 747 WP_000788745.1 ATP-binding protein -
XF37_RS18825 (3617769) 3617769..3618860 - 1092 WP_001205823.1 hypothetical protein -
XF37_RS18830 (3618939) 3618939..3619394 + 456 WP_000273724.1 hypothetical protein -
XF37_RS18835 (3619601) 3619601..3620026 - 426 WP_000693855.1 toxin YdaT family protein -
XF37_RS18840 (3620010) 3620010..3620282 - 273 WP_000887453.1 YdaS family helix-turn-helix protein -
XF37_RS18845 (3620391) 3620391..3620792 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
XF37_RS18850 (3620820) 3620820..3621011 + 192 WP_000536233.1 hypothetical protein Antitoxin
XF37_RS18855 (3621011) 3621011..3621298 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XF37_RS18860 (3621576) 3621576..3621731 + 156 WP_000379575.1 DUF1391 family protein -
XF37_RS28320 (3621733) 3621733..3621861 + 129 WP_000344963.1 protein YdfB -
XF37_RS18865 (3621873) 3621873..3622262 + 390 WP_000394511.1 hypothetical protein -
XF37_RS18870 (3622449) 3622449..3622634 - 186 WP_001133046.1 hypothetical protein -
XF37_RS18875 (3623208) 3623208..3623396 + 189 WP_000413705.1 cell division inhibition protein DicB -
XF37_RS18880 (3623393) 3623393..3623584 + 192 WP_001098307.1 DUF1482 family protein -
XF37_RS18885 (3623678) 3623678..3626149 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T204785 WP_001303876.1 NZ_CP076230:3621011-3621298 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T204785 NZ_CP101251:c629753-629289 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT204785 WP_000536233.1 NZ_CP076230:3620820-3621011 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT204785 NZ_CP101251:c630088-629753 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References