Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1250814..1251463 Replicon chromosome
Accession NZ_CP076136
Organism Bradyrhizobium sediminis strain S2-11-4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KMZ93_RS06030 Protein ID WP_215605206.1
Coordinates 1251062..1251463 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KMZ93_RS06025 Protein ID WP_215605205.1
Coordinates 1250814..1251065 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ93_RS06010 (KMZ93_06010) 1247489..1249081 - 1593 WP_215605202.1 gamma-glutamyltransferase -
KMZ93_RS06015 (KMZ93_06015) 1249181..1249954 + 774 WP_215605203.1 enoyl-CoA hydratase-related protein -
KMZ93_RS06020 (KMZ93_06020) 1250072..1250461 + 390 WP_215605204.1 hypothetical protein -
KMZ93_RS06025 (KMZ93_06025) 1250814..1251065 + 252 WP_215605205.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KMZ93_RS06030 (KMZ93_06030) 1251062..1251463 + 402 WP_215605206.1 type II toxin-antitoxin system VapC family toxin Toxin
KMZ93_RS06035 (KMZ93_06035) 1251926..1252696 + 771 WP_215605207.1 hypothetical protein -
KMZ93_RS06040 (KMZ93_06040) 1253010..1253276 - 267 WP_215605208.1 HGGxSTG domain-containing protein -
KMZ93_RS06045 (KMZ93_06045) 1253273..1253872 - 600 WP_249779276.1 hypothetical protein -
KMZ93_RS06055 (KMZ93_06055) 1254693..1255883 - 1191 WP_215605209.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14340.33 Da        Isoelectric Point: 5.1941

>T204696 WP_215605206.1 NZ_CP076136:1251062-1251463 [Bradyrhizobium sediminis]
MIVVDSSAVIAIFRQEEDAGDYARRIAADDDPVMSAANLVETSIVLRGLKKIAPEKAERWLDDFMKAAGIRIEPVTPDQA
QAARSAHRRFGKGTGHSAALNYGDCFSYALAKLMDAPLLCKGNDFPSTDIGIA

Download         Length: 402 bp

>T204696 NZ_CP101213:8899-9147 [Escherichia coli]
ATGGGGAAAGCAGATAAGCTACTGGCAAAATTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTCGTTGTTTTGTT
TTCTTCTCTAGGATATGTCAAAAAGGAAATGCAGGGATCAAGAGTGCGATTTTTCAATGCTGAAATTAATCACACAATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCTATTAAACAGAACTTGAAAGAGGCTGGG
GTTTTATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9116.26 Da        Isoelectric Point: 6.7261

>AT204696 WP_215605205.1 NZ_CP076136:1250814-1251065 [Bradyrhizobium sediminis]
MHLNIKNDEAHKLASELAQLTGESLTSAVTLALRERLARERRRSRADRVAASLMKIGSEYAALADTGRSPDEILGYDEHG
LPT

Download         Length: 252 bp

>AT204696 NZ_CP101213:9144-9491 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGTACGGTTGAGCCGGATTTTGAAAATAATATCCTGTATGGAAAGCTGGC
ATTTATTCGTGATCTGGTGACTTATGAGGCAGAAACATTGGCTGACCTGGAACGGGAATTTAAAACATCGGTTGATTTGT
ATTTACAGTCCTGTGTGGAGGACGGAAAGGAGCCTGACACGCCCTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAG
CTGCATCGTCGGGTCGCTGAAATGGCGATGGAAGAAGATTTGTCGCTGAATGCCTTTGTCAATAAGGCACTGGAAAAAGA
AGTCAGTCATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References