Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1139955..1140528 Replicon chromosome
Accession NZ_CP076136
Organism Bradyrhizobium sediminis strain S2-11-4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KMZ93_RS05530 Protein ID WP_249779274.1
Coordinates 1140295..1140528 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KMZ93_RS05525 Protein ID WP_215605117.1
Coordinates 1139955..1140251 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ93_RS05495 (KMZ93_05495) 1135536..1136549 - 1014 WP_249779187.1 RluA family pseudouridine synthase -
KMZ93_RS26250 1136548..1136886 + 339 WP_249779188.1 hypothetical protein -
KMZ93_RS05505 (KMZ93_05505) 1137023..1137541 + 519 WP_215605114.1 DUF2846 domain-containing protein -
KMZ93_RS05515 (KMZ93_05515) 1137997..1138752 + 756 WP_215605115.1 hypothetical protein -
KMZ93_RS05520 (KMZ93_05520) 1139536..1139907 + 372 WP_215605116.1 putative addiction module antidote protein -
KMZ93_RS05525 (KMZ93_05525) 1139955..1140251 - 297 WP_215605117.1 HigA family addiction module antitoxin Antitoxin
KMZ93_RS05530 (KMZ93_05530) 1140295..1140528 - 234 WP_249779274.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ93_RS05535 (KMZ93_05535) 1140656..1140922 - 267 WP_215605119.1 HGGxSTG domain-containing protein -
KMZ93_RS05540 (KMZ93_05540) 1140919..1141581 - 663 Protein_1089 hypothetical protein -
KMZ93_RS05545 (KMZ93_05545) 1141997..1142416 - 420 WP_215605120.1 CBS domain-containing protein -
KMZ93_RS05550 (KMZ93_05550) 1142680..1145466 + 2787 WP_215605121.1 UPF0182 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-77)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8622.92 Da        Isoelectric Point: 7.2027

>T204695 WP_249779274.1 NZ_CP076136:c1140528-1140295 [Bradyrhizobium sediminis]
MVPKGFPANLAKVARRKLIMVDSADLLEALNSPPGNRLEALKGDLAGKHSIRINDQWRVVFRWTDAGPEDVEIVDYH

Download         Length: 234 bp

>T204695 NZ_CP101213:7053-7307 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11020.95 Da        Isoelectric Point: 10.0424

>AT204695 WP_215605117.1 NZ_CP076136:c1140251-1139955 [Bradyrhizobium sediminis]
MARKLPPVHPGEVLREEFLVPLKLTPYAVAAALNVPRTRIERIAREEKPVTADTALRLGKFFKTGAAFWMNMQARFDLET
AEDVLAPQIKKIASYEAV

Download         Length: 297 bp

>AT204695 NZ_CP101213:7304-7546 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References