Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1748447..1749039 Replicon chromosome
Accession NZ_CP075881
Organism Klebsiella michiganensis strain JNQH491

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag KLH67_RS08225 Protein ID WP_004105955.1
Coordinates 1748665..1749039 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag KLH67_RS08220 Protein ID WP_004105957.1
Coordinates 1748447..1748668 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KLH67_RS08200 (KLH67_08200) 1744004..1744558 + 555 WP_014226934.1 YgjV family protein -
KLH67_RS08205 (KLH67_08205) 1744577..1745824 - 1248 WP_048260489.1 serine/threonine transporter SstT -
KLH67_RS08210 (KLH67_08210) 1746079..1747047 - 969 WP_048260487.1 TerC family protein -
KLH67_RS08215 (KLH67_08215) 1747298..1748287 - 990 WP_049083892.1 Gfo/Idh/MocA family oxidoreductase -
KLH67_RS08220 (KLH67_08220) 1748447..1748668 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KLH67_RS08225 (KLH67_08225) 1748665..1749039 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KLH67_RS08230 (KLH67_08230) 1749019..1749522 - 504 WP_025108311.1 M48 family metallopeptidase -
KLH67_RS08235 (KLH67_08235) 1749601..1751244 - 1644 WP_049083891.1 glycoside hydrolase family 43 protein -
KLH67_RS08240 (KLH67_08240) 1751373..1752239 - 867 WP_048260480.1 helix-turn-helix transcriptional regulator -
KLH67_RS08245 (KLH67_08245) 1752347..1753690 + 1344 WP_154904458.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T204441 WP_004105955.1 NZ_CP075881:1748665-1749039 [Klebsiella michiganensis]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

>T204441 NZ_CP100728:2058900-2059003 [Salmonella enterica subsp. enterica serovar Blockley]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT204441 WP_004105957.1 NZ_CP075881:1748447-1748668 [Klebsiella michiganensis]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp

>AT204441 NZ_CP100728:c2059005-2058860 [Salmonella enterica subsp. enterica serovar Blockley]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References