Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 211963..212795 Replicon chromosome
Accession NZ_CP075737
Organism Escherichia coli strain CPF6

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag KKZ13_RS01010 Protein ID WP_094321592.1
Coordinates 212418..212795 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KKZ13_RS01005 Protein ID WP_094321594.1
Coordinates 211963..212328 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KKZ13_RS00985 (209712) 209712..210530 + 819 WP_001234393.1 DUF932 domain-containing protein -
KKZ13_RS00990 (210622) 210622..211107 + 486 WP_094321476.1 antirestriction protein -
KKZ13_RS00995 (211123) 211123..211599 + 477 WP_001186181.1 RadC family protein -
KKZ13_RS01000 (211668) 211668..211889 + 222 WP_094321593.1 DUF987 domain-containing protein -
KKZ13_RS01005 (211963) 211963..212328 + 366 WP_094321594.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KKZ13_RS01010 (212418) 212418..212795 + 378 WP_094321592.1 TA system toxin CbtA family protein Toxin
KKZ13_RS01015 (212792) 212792..213280 + 489 WP_094321591.1 DUF5983 family protein -
KKZ13_RS01020 (213292) 213292..213489 + 198 WP_000839285.1 DUF957 domain-containing protein -
KKZ13_RS01025 (213586) 213586..214428 + 843 WP_072650511.1 DUF4942 domain-containing protein -
KKZ13_RS01035 (214899) 214899..215837 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
KKZ13_RS01040 (215892) 215892..216629 + 738 WP_089075151.1 zinc-binding phosphatase -
KKZ13_RS01045 (216653) 216653..217207 + 555 WP_001001921.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14245.17 Da        Isoelectric Point: 7.2912

>T204369 WP_094321592.1 NZ_CP075737:212418-212795 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T204369 NZ_CP100710:887410-887808 [Salmonella enterica subsp. enterica serovar Blockley]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACGTCAAAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13538.38 Da        Isoelectric Point: 6.6247

>AT204369 WP_094321594.1 NZ_CP075737:211963-212328 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 366 bp

>AT204369 NZ_CP100710:887183-887410 [Salmonella enterica subsp. enterica serovar Blockley]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGATGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References