Detailed information of TA system TA204354

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4083509..4083767
• Replicon: chromosome
• Accession: NZ_CP075731
• Organism: Escherichia coli strain CP52E

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KKZ11_RS19765
• Protein ID: WP_000809168.1
• Coordinates: 4083615..4083767 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4083509..4083566 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KKZ11_RS19750	4079475..4080968	-	1494	WP_001173014.1	sulfatase-like hydrolase/transferase	-
KKZ11_RS19755	4080988..4081749	-	762	WP_136698536.1	outer membrane protein OmpK	-
KKZ11_RS19760	4082178..4083347	-	1170	Protein_3870	IS3-like element ISEc52 family transposase	-
-	4083509..4083566	-	58	-	-	Antitoxin
KKZ11_RS19765	4083615..4083767	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
KKZ11_RS19770	4083845..4084957	+	1113	WP_001300563.1	IS4-like element IS421 family transposase	-
KKZ11_RS19775	4085220..4086350	-	1131	WP_136698537.1	molecular chaperone DnaJ	-
KKZ11_RS19780	4086439..4088355	-	1917	WP_000516135.1	molecular chaperone DnaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4070980..4085120	14140
	-	inside	IScluster/Tn	-	-	4082200..4085120	2920

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T204354 WP_000809168.1 NZ_CP075731:4083615-4083767 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T204354 NZ_CP100707:2433642-2433926 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT204354 NZ_CP075731:c4083566-4083509 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin