Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/Xre(antitoxin) |
| Location | 8103..8605 | Replicon | plasmid pS19_141-b |
| Accession | NZ_CP075642 | ||
| Organism | Escherichia coli strain S19-141 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A827KMD4 |
| Locus tag | JFX59_RS25235 | Protein ID | WP_042968288.1 |
| Coordinates | 8103..8360 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | A0A2S5RIE4 |
| Locus tag | JFX59_RS25240 | Protein ID | WP_022645142.1 |
| Coordinates | 8354..8605 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JFX59_RS25185 (JFX59_025185) | 3451..4116 | - | 666 | WP_000532148.1 | division plane positioning ATPase MipZ | - |
| JFX59_RS25190 (JFX59_025190) | 4620..4949 | + | 330 | WP_047082006.1 | hypothetical protein | - |
| JFX59_RS25195 (JFX59_025195) | 5119..5415 | + | 297 | WP_042968292.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| JFX59_RS25200 (JFX59_025200) | 5417..5701 | + | 285 | WP_047082007.1 | putative addiction module antidote protein | - |
| JFX59_RS25205 (JFX59_025205) | 5954..6208 | + | 255 | WP_086217910.1 | hypothetical protein | - |
| JFX59_RS25210 (JFX59_025210) | 6205..6441 | + | 237 | WP_047082009.1 | transcriptional regulator | - |
| JFX59_RS25215 (JFX59_025215) | 6453..6599 | + | 147 | WP_155953439.1 | hypothetical protein | - |
| JFX59_RS25220 (JFX59_025220) | 7153..7479 | + | 327 | WP_032716095.1 | hypothetical protein | - |
| JFX59_RS25225 (JFX59_025225) | 7520..7729 | + | 210 | WP_032716096.1 | hypothetical protein | - |
| JFX59_RS25230 (JFX59_025230) | 7827..8051 | + | 225 | WP_000814383.1 | hypothetical protein | - |
| JFX59_RS25235 (JFX59_025235) | 8103..8360 | + | 258 | WP_042968288.1 | hypothetical protein | Toxin |
| JFX59_RS25240 (JFX59_025240) | 8354..8605 | + | 252 | WP_022645142.1 | transcriptional regulator | Antitoxin |
| JFX59_RS25245 (JFX59_025245) | 9143..9448 | + | 306 | WP_072096363.1 | hypothetical protein | - |
| JFX59_RS25250 (JFX59_025250) | 9754..10041 | + | 288 | WP_000606467.1 | hypothetical protein | - |
| JFX59_RS25255 (JFX59_025255) | 10469..10702 | + | 234 | WP_000093744.1 | hypothetical protein | - |
| JFX59_RS25260 (JFX59_025260) | 10775..11080 | + | 306 | WP_047081935.1 | hypothetical protein | - |
| JFX59_RS25265 (JFX59_025265) | 11703..11885 | + | 183 | WP_047081936.1 | type II toxin-antitoxin system HicA family toxin | - |
| JFX59_RS25270 (JFX59_025270) | 11910..12347 | + | 438 | WP_047081937.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| JFX59_RS25275 (JFX59_025275) | 12422..12610 | - | 189 | WP_047081938.1 | DUF5397 family protein | - |
| JFX59_RS25280 (JFX59_025280) | 12864..13535 | - | 672 | WP_047081939.1 | DUF47 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..42892 | 42892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9808.25 Da Isoelectric Point: 8.0264
>T204081 WP_042968288.1 NZ_CP075642:8103-8360 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EEKKC
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEEAFDTIDFASDGLRENDKEIVSMMIQEMS
EEKKC
Download Length: 258 bp
>T204081 NZ_CP100530:1861263-1861517 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTATAGAGGAACACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9407.81 Da Isoelectric Point: 9.8120
>AT204081 WP_022645142.1 NZ_CP075642:8354-8605 [Escherichia coli]
MLTENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
MLTENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN
Download Length: 252 bp
>AT204081 NZ_CP100530:1861015-1861266 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCACCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A827KMD4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S5RIE4 |