Detailed information of TA system TA020372

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-agrB/Ldr(toxin)
• Location: 4442251..4442472
• Replicon: chromosome
• Accession: NC_002695
• Organism: Escherichia coli O157:H7 str. Sakai

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: -
• Locus tag: ECs_5758
• Protein ID: YP_009502657.1
• Coordinates: 4442251..4442358 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	4442407..4442472 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECs_4415	4438268..4438456	-	189	NP_312442.1	hypothetical protein	-
ECs_4416	4438741..4440300	+	1560	NP_312443.2	cellulose production protein	-
ECs_4417	4440297..4440488	+	192	NP_312444.2	cellulose biosynthesis protein BcsF	-
ECs_4418	4440485..4442164	+	1680	NP_312445.1	cellulose biosynthesis protein BcsG	-
ECs_5758	4442251..4442358	-	108	YP_009502657.1	hypothetical protein	Toxin
-	4442407..4442472	+	66	-	-	Antitoxin
ECs_4419	4442834..4444105	+	1272	NP_312446.1	transporter	-
ECs_4420	4444135..4445139	-	1005	NP_312447.1	dipeptide/heme ABC transporter ATPase	-
ECs_4421	4445136..4446119	-	984	NP_312448.1	dipeptide/heme ABC transporter ATPase	-
ECs_4422	4446130..4447032	-	903	NP_312449.1	dipeptide/heme ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T20372 YP_009502657.1 NC_002695:c4442358-4442251 [Escherichia coli O157:H7 str. Sakai]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T20372 NC_002695:c4442358-4442251 [Escherichia coli O157:H7 str. Sakai]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT20372 NC_002695:4442407-4442472 [Escherichia coli O157:H7 str. Sakai]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Antitoxin