Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4211264..4212099 | Replicon | chromosome |
| Accession | NZ_CP075469 | ||
| Organism | Escherichia coli strain NT1W22 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | IGI32_RS20525 | Protein ID | WP_089614471.1 |
| Coordinates | 4211722..4212099 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7W3AJG7 |
| Locus tag | IGI32_RS20520 | Protein ID | WP_001389198.1 |
| Coordinates | 4211264..4211632 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IGI32_RS20485 (4207221) | 4207221..4207898 | + | 678 | WP_001097362.1 | hypothetical protein | - |
| IGI32_RS20490 (4207904) | 4207904..4208137 | + | 234 | WP_001278288.1 | DUF905 family protein | - |
| IGI32_RS20495 (4208227) | 4208227..4209045 | + | 819 | WP_001175170.1 | DUF932 domain-containing protein | - |
| IGI32_RS20500 (4209122) | 4209122..4209607 | + | 486 | WP_000213717.1 | antirestriction protein | - |
| IGI32_RS20505 (4209623) | 4209623..4210099 | + | 477 | WP_001186744.1 | RadC family protein | - |
| IGI32_RS20515 (4210963) | 4210963..4211184 | + | 222 | WP_000692287.1 | DUF987 domain-containing protein | - |
| IGI32_RS20520 (4211264) | 4211264..4211632 | + | 369 | WP_001389198.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| IGI32_RS20525 (4211722) | 4211722..4212099 | + | 378 | WP_089614471.1 | TA system toxin CbtA family protein | Toxin |
| IGI32_RS20530 (4212096) | 4212096..4212584 | + | 489 | WP_000761678.1 | DUF5983 family protein | - |
| IGI32_RS20535 (4212596) | 4212596..4212793 | + | 198 | WP_000839291.1 | DUF957 domain-containing protein | - |
| IGI32_RS20540 (4212878) | 4212878..4213726 | + | 849 | WP_159185536.1 | DUF4942 domain-containing protein | - |
| IGI32_RS20545 (4213999) | 4213999..4214649 | - | 651 | WP_000056760.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
| IGI32_RS20550 (4214663) | 4214663..4215127 | - | 465 | WP_000776505.1 | PTS ascorbate transporter subunit IIA | - |
| IGI32_RS20555 (4215137) | 4215137..4215442 | - | 306 | WP_000218362.1 | PTS ascorbate transporter subunit IIB | - |
| IGI32_RS20560 (4215458) | 4215458..4216855 | - | 1398 | WP_151140407.1 | PTS ascorbate transporter subunit IIC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4165831..4213989 | 48158 | |
| - | flank | IS/Tn | - | - | 4210172..4210675 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14079.17 Da Isoelectric Point: 8.2830
>T203664 WP_089614471.1 NZ_CP075469:4211722-4212099 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ
MKTLPDTLVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T203664 NZ_CP100238:3013914-3014096 [Burkholderia glumae]
ATGAACAGCGCGAACCTTATCCGAACCCTGAAAGCCGACGGCTGGTATCTCGTCAATACCGTCGGCTCGCATCACCAGTT
CAAGCATGCGACCAAGCCCGGTAAGGTGACGGTGCCTCACCCGAAGAAAGACCTTCCCCTAGGCACCGTGCGCAGCATCC
TGAAACAAGCCGGTCTGAAATGA
ATGAACAGCGCGAACCTTATCCGAACCCTGAAAGCCGACGGCTGGTATCTCGTCAATACCGTCGGCTCGCATCACCAGTT
CAAGCATGCGACCAAGCCCGGTAAGGTGACGGTGCCTCACCCGAAGAAAGACCTTCCCCTAGGCACCGTGCGCAGCATCC
TGAAACAAGCCGGTCTGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13610.39 Da Isoelectric Point: 6.3159
>AT203664 WP_001389198.1 NZ_CP075469:4211264-4211632 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT203664 NZ_CP100238:3014123-3014518 [Burkholderia glumae]
ATGCTCTATCCGCTCTATGTCCACGTCGGCGACGACAAGCACGCACATGGCGTCACTTTTCCCGACTTCCCCGGCTGCCA
CGCTGCGGCCGACTCCTGGGACGAACTGCCCGCAGCCGTGCAGGAGGCCGCCCAGGCCCATTTCGAGGGCGACGACAGCC
CGATTCCCGAGCCTTCCGCGCTCGAAGATTTGACGCGCGATCCGGAATACACCGGCGGCGTCTGGATGATCTTCGATATC
GACCTGTCGAAGATCAACACGAAAGCCGTGCGCTTCAACGTCAGCATGTCCGAGCGGCTGCTCCAGAAGATCGACGCCAA
GGCGCGCGCGCGCAAACTCTCGCGATCGGCCTTCCTTGCGATTGCGGCAGAACACGAAATGGAAGCTGACGCCTAA
ATGCTCTATCCGCTCTATGTCCACGTCGGCGACGACAAGCACGCACATGGCGTCACTTTTCCCGACTTCCCCGGCTGCCA
CGCTGCGGCCGACTCCTGGGACGAACTGCCCGCAGCCGTGCAGGAGGCCGCCCAGGCCCATTTCGAGGGCGACGACAGCC
CGATTCCCGAGCCTTCCGCGCTCGAAGATTTGACGCGCGATCCGGAATACACCGGCGGCGTCTGGATGATCTTCGATATC
GACCTGTCGAAGATCAACACGAAAGCCGTGCGCTTCAACGTCAGCATGTCCGAGCGGCTGCTCCAGAAGATCGACGCCAA
GGCGCGCGCGCGCAAACTCTCGCGATCGGCCTTCCTTGCGATTGCGGCAGAACACGAAATGGAAGCTGACGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|