Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3124501..3125414 Replicon chromosome
Accession NZ_CP075345
Organism Enterobacter kobei strain S18_CRE18

Toxin (Protein)


Gene name - Uniprot ID A0A2J0PLX5
Locus tag KJE18_RS14925 Protein ID WP_023337016.1
Coordinates 3124941..3125414 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J0PMR8
Locus tag KJE18_RS14920 Protein ID WP_023337017.1
Coordinates 3124501..3124944 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJE18_RS14905 (KJE18_14885) 3120310..3122031 + 1722 WP_014883200.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -
KJE18_RS14910 (KJE18_14890) 3122077..3122781 + 705 WP_023337019.1 leucyl/phenylalanyl-tRNA--protein transferase -
KJE18_RS14915 (KJE18_14895) 3123066..3123284 + 219 WP_002211347.1 translation initiation factor IF-1 -
KJE18_RS14920 (KJE18_14900) 3124501..3124944 + 444 WP_023337017.1 DUF2384 domain-containing protein Antitoxin
KJE18_RS14925 (KJE18_14905) 3124941..3125414 + 474 WP_023337016.1 RES domain-containing protein Toxin
KJE18_RS14930 (KJE18_14910) 3125436..3125990 - 555 WP_023337015.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
KJE18_RS14935 (KJE18_14915) 3126000..3126998 - 999 WP_038421207.1 type I-F CRISPR-associated protein Csy3 -
KJE18_RS14940 (KJE18_14920) 3127012..3127947 - 936 WP_023337013.1 type I-F CRISPR-associated protein Csy2 -
KJE18_RS14945 (KJE18_14925) 3127944..3128966 - 1023 WP_225990831.1 type I-F CRISPR-associated protein Csy1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17570.82 Da        Isoelectric Point: 5.0700

>T203500 WP_023337016.1 NZ_CP075345:3124941-3125414 [Enterobacter kobei]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPSFHTALNSVQQLPFNFDTRLAEKTAP

Download         Length: 474 bp

>T203500 NZ_CP100106:343872-344240 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16349.68 Da        Isoelectric Point: 7.2062

>AT203500 WP_023337017.1 NZ_CP075345:3124501-3124944 [Enterobacter kobei]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT203500 NZ_CP100106:343654-343875 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGTGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLX5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PMR8

References