Detailed information of TA system TA203252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4686045..4686799
• Replicon: chromosome
• Accession: NZ_CP075138
• Organism: Salmonella enterica strain CFSAN044875

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Z1E8E0
• Locus tag: A7R97_RS22830
• Protein ID: WP_000558163.1
• Coordinates: 4686045..4686356 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: A7R97_RS22835
• Protein ID: WP_001259011.1
• Coordinates: 4686353..4686799 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7R97_RS22800 (4681703)	4681703..4682605	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
A7R97_RS22805 (4682602)	4682602..4683237	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
A7R97_RS22810 (4683234)	4683234..4684163	+	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
A7R97_RS22815 (4684210)	4684210..4684500	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
A7R97_RS22820 (4684501)	4684501..4684812	-	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
A7R97_RS22825 (4685030)	4685030..4685959	+	930	WP_001627365.1	alpha/beta hydrolase	-
A7R97_RS22830 (4686045)	4686045..4686356	+	312	WP_000558163.1	type II toxin-antitoxin system HigB family toxin	Toxin
A7R97_RS22835 (4686353)	4686353..4686799	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
A7R97_RS22840 (4686814)	4686814..4687755	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
A7R97_RS22845 (4687800)	4687800..4688237	-	438	WP_001627364.1	D-aminoacyl-tRNA deacylase	-
A7R97_RS22850 (4688234)	4688234..4689106	-	873	WP_001627363.1	virulence factor BrkB family protein	-
A7R97_RS22855 (4689100)	4689100..4689699	-	600	WP_000965695.1	glucose-1-phosphatase	-
A7R97_RS22860 (4689890)	4689890..4690693	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
A7R97_RS22865 (4690727)	4690727..4691623	-	897	WP_001627362.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12406.36 Da
• Isoelectric Point: 9.5921

>T203252 WP_000558163.1 NZ_CP075138:4686045-4686356 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T203252 NZ_CP099903:1923482-1923814 [Escherichia albertii]
ATGGACAGAGGAGAAATCTGGCTTGTTTCACTTGACCCTATCGCCGGGCATGAGCAAAGCGGAAAACGCCCGGTGCTTAT
CGTTTCTCCGGCCTCGTTTAACGAGGTCACCCGGTTGCCCGTCATTGTTCCGGTAACCAGCGGTGGGCAATTTGCCCGTA
GCGCGGGTTTTGCGGTTTCGCTGGAGGGCGCTGGCACAAAAACGACGGGGATTATTCGTTGCGATCAGCCCAGAACCATT
GATATGGGAGCCCGAAACGGTAAGCGGCTGGAGCGCATACCTGACGGTATCATCAACGAGGTGCTGGCAAGGCTGGAAAC
CATCCTGGCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT203252 WP_001259011.1 NZ_CP075138:4686353-4686799 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT203252 NZ_CP099903:1923224-1923481 [Escherichia albertii]
ATGTATACCACACGTCTGAAAAAGGTTGGCGGTTCTGTCATGCTGGCTGTTCCGCCCGCCGTGCTGAAAACGCTGGCCCT
GTTGCCGGACAGCGAAGTCGGTGTAACCATCGACAACGGCTGCCTGATTATCGAACCGCAAAAACGACCACGCTATTCAC
TGGCCGAACTGCTGGCGCAATGCGATCCCCATGAAGAAATCAGTGATGAGGAGCGCGAATGGATTGATGCGCCTGCCGCA
GGGAAGGAGATCCTGTAA

Structures

Toxin

• AlphaFold DB: A0A3Z1E8E0