Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4684210..4684812 Replicon chromosome
Accession NZ_CP075138
Organism Salmonella enterica strain CFSAN044875

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag A7R97_RS22820 Protein ID WP_001159635.1
Coordinates 4684501..4684812 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag A7R97_RS22815 Protein ID WP_000362050.1
Coordinates 4684210..4684500 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R97_RS22800 (4681703) 4681703..4682605 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
A7R97_RS22805 (4682602) 4682602..4683237 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
A7R97_RS22810 (4683234) 4683234..4684163 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
A7R97_RS22815 (4684210) 4684210..4684500 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
A7R97_RS22820 (4684501) 4684501..4684812 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
A7R97_RS22825 (4685030) 4685030..4685959 + 930 WP_001627365.1 alpha/beta hydrolase -
A7R97_RS22830 (4686045) 4686045..4686356 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
A7R97_RS22835 (4686353) 4686353..4686799 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
A7R97_RS22840 (4686814) 4686814..4687755 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
A7R97_RS22845 (4687800) 4687800..4688237 - 438 WP_001627364.1 D-aminoacyl-tRNA deacylase -
A7R97_RS22850 (4688234) 4688234..4689106 - 873 WP_001627363.1 virulence factor BrkB family protein -
A7R97_RS22855 (4689100) 4689100..4689699 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T203251 WP_001159635.1 NZ_CP075138:c4684812-4684501 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T203251 NZ_CP099903:1054280-1054432 [Escherichia albertii]
ATGCTAACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GCTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT203251 WP_000362050.1 NZ_CP075138:c4684500-4684210 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT203251 NZ_CP099903:c1054238-1054186 [Escherichia albertii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References