Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 878017..878677 Replicon chromosome
Accession NZ_CP075138
Organism Salmonella enterica strain CFSAN044875

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag A7R97_RS04315 Protein ID WP_000244756.1
Coordinates 878264..878677 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7R97_RS04310 Protein ID WP_000351186.1
Coordinates 878017..878283 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7R97_RS04290 (873945) 873945..875378 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
A7R97_RS04295 (875537) 875537..875848 + 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
A7R97_RS04300 (876012) 876012..876671 + 660 WP_000250289.1 hemolysin III family protein -
A7R97_RS04305 (876787) 876787..877767 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
A7R97_RS04310 (878017) 878017..878283 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7R97_RS04315 (878264) 878264..878677 + 414 WP_000244756.1 protein YgfX Toxin
A7R97_RS04320 (878730) 878730..879251 - 522 WP_001055885.1 flavodoxin FldB -
A7R97_RS04325 (879364) 879364..880260 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7R97_RS04330 (880284) 880284..880997 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7R97_RS04335 (881003) 881003..882736 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T203237 WP_000244756.1 NZ_CP075138:878264-878677 [Salmonella enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T203237 NZ_CP099898:2063439-2063542 [Escherichia albertii]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAAAAC
AGGAATCGTTTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203237 WP_000351186.1 NZ_CP075138:878017-878283 [Salmonella enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203237 NZ_CP099898:c2063544-2063312 [Escherichia albertii]
ATAAAAAGAGACCGAAAACGATTCCTGTTTTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTACAAAATGGTCAG
TAAAAAGCGCGTCGGCCATCGTCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGTGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References