Detailed information of TA system TA203211

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 86720..87432
• Replicon: chromosome
• Accession: NZ_CP075137
• Organism: Salmonella enterica strain CFSAN044885

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A8F0CU93
• Locus tag: A7S07_RS00420
• Protein ID: WP_023216836.1
• Coordinates: 86720..87088 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A8E7K1A9
• Locus tag: A7S07_RS00425
• Protein ID: WP_023216835.1
• Coordinates: 87103..87432 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S07_RS00390 (82253)	82253..82384	-	132	WP_023216841.1	hypothetical protein	-
A7S07_RS00395 (82765)	82765..83104	+	340	Protein_78	transposase	-
A7S07_RS00400 (83511)	83511..84344	-	834	WP_023216839.1	DUF4942 domain-containing protein	-
A7S07_RS00405 (84498)	84498..85220	-	723	WP_077957236.1	retron system putative HNH endonuclease	-
A7S07_RS00410 (85217)	85217..85438	-	222	WP_133297822.1	hypothetical protein	-
A7S07_RS00415 (85423)	85423..86626	-	1204	Protein_82	AAA family ATPase	-
A7S07_RS00420 (86720)	86720..87088	-	369	WP_023216836.1	TA system toxin CbtA family protein	Toxin
A7S07_RS00425 (87103)	87103..87432	-	330	WP_023216835.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
A7S07_RS00430 (87495)	87495..87995	-	501	WP_023216834.1	DNA repair protein RadC	-
A7S07_RS00435 (88008)	88008..88829	-	822	Protein_86	DUF945 domain-containing protein	-
A7S07_RS00440 (88914)	88914..89828	-	915	WP_023216831.1	hypothetical protein	-
A7S07_RS00445 (89893)	89893..90096	-	204	WP_023216830.1	hypothetical protein	-
A7S07_RS00450 (90113)	90113..90331	-	219	WP_000928654.1	hypothetical protein	-
A7S07_RS00455 (90332)	90332..91045	-	714	WP_023216829.1	WYL domain-containing protein	-
A7S07_RS00460 (91427)	91427..91795	+	369	WP_165850589.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	82253..100180	17927

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (11-109)

Antitoxin

• Antitoxin CbeA (10-108)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13735.76 Da
• Isoelectric Point: 9.0721

>T203211 WP_023216836.1 NZ_CP075137:c87088-86720 [Salmonella enterica]
MQNVLSLPSPAAASSRLSPVEAWQKLLSYLLQRHYGLELNDTPFCDDIVIQEHINAGVALADAVNFLVEKYGLVRIDRKG
FSWQEQSPYLRAVDILRARKATGLLTRCKKHNGNQPDGRFTL

Nucleotide

• Length: 369 bp

>T203211 NZ_CP099895:142139-142324 [Escherichia albertii]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12104.58 Da
• Isoelectric Point: 6.4711

>AT203211 WP_023216835.1 NZ_CP075137:c87432-87103 [Salmonella enterica]
MPQNQPSAPVWGLRSDITPSFGARLVQEGCRLHFLPDRASLRGDFTAEQLHSLDITFPQFVKQLESALKSGALDPHQSRR
YSTILNGLTCEADTNGSHGYVYLTIYPAE

Nucleotide

• Length: 330 bp

>AT203211 NZ_CP099895:142341-142751 [Escherichia albertii]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGGGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTTCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGGTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA