Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2778402..2779062 Replicon chromosome
Accession NZ_CP075132
Organism Salmonella enterica subsp. enterica serovar Inverness strain CFSAN044911

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag A7S33_RS13840 Protein ID WP_000244756.1
Coordinates 2778402..2778815 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag A7S33_RS13845 Protein ID WP_000351186.1
Coordinates 2778796..2779062 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S33_RS13820 (2774343) 2774343..2776076 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
A7S33_RS13825 (2776082) 2776082..2776795 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
A7S33_RS13830 (2776819) 2776819..2777715 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
A7S33_RS13835 (2777828) 2777828..2778349 + 522 WP_001055885.1 flavodoxin FldB -
A7S33_RS13840 (2778402) 2778402..2778815 - 414 WP_000244756.1 protein YgfX Toxin
A7S33_RS13845 (2778796) 2778796..2779062 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
A7S33_RS13850 (2779312) 2779312..2780292 + 981 WP_000874176.1 tRNA-modifying protein YgfZ -
A7S33_RS13855 (2780408) 2780408..2781067 - 660 WP_000250289.1 hemolysin III family protein -
A7S33_RS13860 (2781231) 2781231..2781542 - 312 WP_001182970.1 N(4)-acetylcytidine aminohydrolase -
A7S33_RS13865 (2781701) 2781701..2783134 + 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T203166 WP_000244756.1 NZ_CP075132:c2778815-2778402 [Salmonella enterica subsp. enterica serovar Inverness]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T203166 NZ_CP099887:930405-930809 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT203166 WP_000351186.1 NZ_CP075132:c2779062-2778796 [Salmonella enterica subsp. enterica serovar Inverness]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT203166 NZ_CP099887:930158-930424 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References