Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4384050..4384831 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag A7S43_RS21390 Protein ID WP_000625912.1
Coordinates 4384050..4384541 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag A7S43_RS21395 Protein ID WP_001110450.1
Coordinates 4384538..4384831 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS21355 (4379461) 4379461..4379808 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
A7S43_RS21360 (4379784) 4379784..4381487 + 1704 WP_000068889.1 protein-disulfide reductase DsbD -
A7S43_RS21365 (4381524) 4381524..4382099 + 576 WP_001188509.1 transcriptional regulator -
A7S43_RS21375 (4382370) 4382370..4382444 - 75 Protein_4216 helix-turn-helix domain-containing protein -
A7S43_RS21380 (4382824) 4382824..4382901 + 78 Protein_4217 porin family protein -
A7S43_RS21385 (4383001) 4383001..4383753 + 753 WP_070794150.1 non-specific acid phosphatase -
A7S43_RS21390 (4384050) 4384050..4384541 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
A7S43_RS21395 (4384538) 4384538..4384831 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
A7S43_RS24675 (4385148) 4385148..4385357 + 210 Protein_4221 hypothetical protein -
A7S43_RS21400 (4385621) 4385621..4386496 + 876 WP_000921676.1 AraC family transcriptional regulator -
A7S43_RS21405 (4386493) 4386493..4386780 + 288 WP_001269916.1 transcriptional regulator RtsB -
A7S43_RS24680 (4386773) 4386773..4386955 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
A7S43_RS24685 (4386975) 4386975..4387074 + 100 Protein_4225 hypothetical protein -
A7S43_RS24690 (4387184) 4387184..4387318 + 135 Protein_4226 hypothetical protein -
A7S43_RS21415 (4387613) 4387613..4388518 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T203148 WP_000625912.1 NZ_CP075129:c4384541-4384050 [Salmonella enterica subsp. enterica serovar Rubislaw]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203148 NZ_CP099886:2529910-2530251 [Escherichia albertii]
ATGAAAATTATTCCTGCAACGACGCTGCGGGCGACGACGTCATATCTGTCGCCTGTCGTGGTCTGGCAAACATTACTGGC
CCGCCTGCTGGAGCAGCACTACGGGCTGAATCTTAATGACACACCATTCAACAATGAAAAGGTGATTCAGGAACACATAG
ACGCCGGGATCACTCTGGTCGATGCCGTCAATTTTCTGGTGGAGAAGTACGAATTGATCCGTATCGACAGGAAAGGATTT
AGCTGGCAGGAACAGACGCCTTATCTTCGTGCGGTCGATATTTTGCGTGCGAGGCAGGCTACAGGTCTGCTGCGTCGCTG
CCATAACACCACGGCACGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT203148 WP_001110450.1 NZ_CP075129:c4384831-4384538 [Salmonella enterica subsp. enterica serovar Rubislaw]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203148 NZ_CP099886:2529544-2529879 [Escherichia albertii]
ATGCTGCAAAAGGATAAGGTCATGCAACAAGAATGTGGGCTTCCCTGTACCGTAACACCACGCTTCACTGCTCGACTGGT
ACAGGAAAGACATAACCTGCATTACCTGGCTGATCGGGCCGCAATCACCGGGAAATTCAGCTCCCCGGATCTGCTGCATA
TCGACCAGGCTTTTCCGGTGCTGATGAAACAACTGGAGCTGAAACTGGCTGACGATGAACTCTCCGCCTGCCAACAACGT
ACCGTCACACTATACGCCAAAGGACTAACCTGCGAAGCCGATACGCTGGGTTCCTGTGGTTACGTCTATATCGCTATTTA
TCCCACTCAACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References