Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 201866..202626 Replicon chromosome
Accession NZ_CP075129
Organism Salmonella enterica subsp. enterica serovar Rubislaw strain CFSAN044921

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag A7S43_RS00950 Protein ID WP_000533909.1
Coordinates 202141..202626 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag A7S43_RS00945 Protein ID WP_000965886.1
Coordinates 201866..202153 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A7S43_RS24450 (197868) 197868..198323 + 456 Protein_183 IS3 family transposase -
A7S43_RS24455 (198447) 198447..199235 + 789 Protein_184 IS3 family transposase -
A7S43_RS00935 (199793) 199793..200536 + 744 WP_001646634.1 HNH endonuclease -
A7S43_RS00940 (200607) 200607..201233 - 627 WP_130559547.1 hypothetical protein -
A7S43_RS00945 (201866) 201866..202153 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
A7S43_RS00950 (202141) 202141..202626 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
A7S43_RS00955 (202998) 202998..203537 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
A7S43_RS00960 (203710) 203710..203922 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
A7S43_RS00965 (204210) 204210..204500 - 291 WP_000455790.1 HTH-type transcriptional regulator -
A7S43_RS00970 (204939) 204939..205649 + 711 WP_000190524.1 DUF3053 domain-containing protein -
A7S43_RS00975 (205699) 205699..206673 - 975 WP_000804695.1 glyoxylate/hydroxypyruvate reductase GhrB -
A7S43_RS00980 (206892) 206892..207554 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T203135 WP_000533909.1 NZ_CP075129:202141-202626 [Salmonella enterica subsp. enterica serovar Rubislaw]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T203135 NZ_CP099883:c3445710-3445306 [Escherichia albertii]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTCTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGCTATTTTACTCATGCCCTGGCCGCTAAGTTATACCCCGTTATGGATGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TCCGCAGTCAGCGGCGCATTAATGCTCGTCAGGGGGAGATTCGCCTGTTGATGGATGGGCGTTTACGCTGGCAGGGGCAG
GAGTGGAGCATCGTCAGAGCGCCGTGGATGATTAAAACTGGCATGATGTTGCGTTTACTCTCTGATAGCGGCAAACGTCA
GCACCTGTGGCTGGCAGCCGACAGTATGGATGAAGCTGAATGGCGGGATTTGCGGCGAATTTTGTTACAACAAGAGATAC
AGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT203135 WP_000965886.1 NZ_CP075129:201866-202153 [Salmonella enterica subsp. enterica serovar Rubislaw]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT203135 NZ_CP099883:c3445957-3445691 [Escherichia albertii]
ATGGACATTAACAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGATAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGACTGCTGGAATGTGACGATCCCGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGTCGACGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References