Detailed information of TA system TA203119

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 831401..832061
• Replicon: chromosome
• Accession: NZ_CP075128
• Organism: Salmonella enterica subsp. diarizonae serovar 60:r:enxz15 strain CFSAN044923

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E9YGN6
• Locus tag: A7S45_RS04110
• Protein ID: WP_023249207.1
• Coordinates: 831648..832061 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: A7S45_RS04105
• Protein ID: WP_000351186.1
• Coordinates: 831401..831667 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A7S45_RS04085 (827342)	827342..828775	-	1434	WP_023249203.1	6-phospho-beta-glucosidase BglA	-
A7S45_RS04090 (828933)	828933..829244	+	312	WP_023249204.1	N(4)-acetylcytidine aminohydrolase	-
A7S45_RS04095 (829408)	829408..830067	+	660	WP_023249205.1	hemolysin III family protein	-
A7S45_RS04100 (830168)	830168..831148	-	981	WP_023249206.1	tRNA-modifying protein YgfZ	-
A7S45_RS04105 (831401)	831401..831667	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
A7S45_RS04110 (831648)	831648..832061	+	414	WP_023249207.1	protein YgfX	Toxin
A7S45_RS04115 (832113)	832113..832634	-	522	WP_023249208.1	flavodoxin FldB	-
A7S45_RS04120 (832747)	832747..833643	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
A7S45_RS04125 (833667)	833667..834380	+	714	WP_070788883.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
A7S45_RS04130 (834386)	834386..836122	+	1737	WP_023249210.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16283.31 Da
• Isoelectric Point: 11.4501

>T203119 WP_023249207.1 NZ_CP075128:831648-832061 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
VVLWQSELRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLRSGMVLRLRAESGHHQHLWLAADSMEAAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T203119 NZ_CP099880:c4339327-4338950 [Escherichia albertii]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCTGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT203119 WP_000351186.1 NZ_CP075128:831401-831667 [Salmonella enterica subsp. diarizonae serovar 60:r:e,n,x,z15]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT203119 NZ_CP099880:c4339785-4339417 [Escherichia albertii]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCACCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4