Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 18416..18938 Replicon plasmid pCFSAN051827_2
Accession NZ_CP075124
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)


Gene name relE Uniprot ID A9LK42
Locus tag BCA48_RS23130 Protein ID WP_000220562.1
Coordinates 18657..18938 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag BCA48_RS23125 Protein ID WP_000121743.1
Coordinates 18416..18667 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCA48_RS23090 (BCA48_23095) 13625..13936 + 312 WP_000360321.1 hypothetical protein -
BCA48_RS23095 (BCA48_23100) 13974..14594 + 621 WP_012477163.1 hypothetical protein -
BCA48_RS23100 (BCA48_23105) 14619..15254 + 636 WP_012477164.1 hypothetical protein -
BCA48_RS23105 (BCA48_23110) 15285..15638 - 354 WP_000876434.1 DNA distortion polypeptide 3 -
BCA48_RS23110 (BCA48_23115) 15744..16190 - 447 WP_001074382.1 hypothetical protein -
BCA48_RS23115 (BCA48_23120) 16230..17066 - 837 WP_001802123.1 replication initiation protein -
BCA48_RS23120 (BCA48_23125) 17395..17631 + 237 WP_220572326.1 hypothetical protein -
BCA48_RS23510 18193..18324 - 132 WP_001378418.1 hypothetical protein -
BCA48_RS23125 (BCA48_23130) 18416..18667 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
BCA48_RS23130 (BCA48_23135) 18657..18938 + 282 WP_000220562.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCA48_RS23135 (BCA48_23140) 19084..19407 + 324 WP_001181905.1 hypothetical protein -
BCA48_RS23140 (BCA48_23145) 19455..19700 + 246 WP_000356542.1 hypothetical protein -
BCA48_RS23145 (BCA48_23150) 19690..19905 + 216 WP_001180117.1 hypothetical protein -
BCA48_RS23150 (BCA48_23155) 19998..20327 + 330 WP_000866654.1 hypothetical protein -
BCA48_RS23155 (BCA48_23160) 20369..20548 + 180 WP_000439079.1 hypothetical protein -
BCA48_RS23160 (BCA48_23165) 20618..20767 + 150 WP_000003880.1 hypothetical protein -
BCA48_RS23165 (BCA48_23170) 20780..21052 + 273 WP_000160399.1 hypothetical protein -
BCA48_RS23175 (BCA48_23180) 21378..21923 + 546 WP_020801480.1 DNA distortion polypeptide 1 -
BCA48_RS23180 (BCA48_23185) 21926..23092 + 1167 WP_012477147.1 MobP1 family relaxase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33067 33067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-82)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11021.83 Da        Isoelectric Point: 10.5938

>T203077 WP_000220562.1 NZ_CP075124:18657-18938 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVISVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T203077 NZ_CP099874:2416718-2417104 [Escherichia albertii]
ATGATTTGGGTCAGTGCACAGGAGGTCATTGCCTTCCACGATCGAATTTTGCAACGTTTTCCCGGTGTGGCGGGCCTGAC
TGACCCCGGCAGAGCACAGGCGTTGATTTATCGCGTGCAGAATCGTGTTCACTACGAGGGCGTTACTGACCTGTTTGAAC
TGGCAGCAACCTACTGGGTTGCCATCGCTCGCGGTCACATCTTTCATGATGGTAATAAACGTACCGCATTTTTCGTTACT
ATGACCTTTCTTTGGCGCAATGGCATCCGTATCCGTGACGTTGATAACTCGCTGGAGAACCTGACTGTCGAAGCGGCTAC
CGGAGAAAAAACGGTCGGTCAATTAGCGCGATGTTTACGTGAACGAGTGGATAGTTCCGGGAATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT203077 WP_000121743.1 NZ_CP075124:18416-18667 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT203077 NZ_CP099874:2416500-2416721 [Escherichia albertii]
ATGCAAACTTACACTTCCACACAAGCCAGAGCCAATATTGCCACTGTACTGGATACCGCGTTGAATGGTGAGCCAGTTGA
AATCACCCGTCGCGACGGCAGCTCTGCCGTGCTCATTAGTAAAGCCGCATTCGAGGCGTATCAAAATGCGAAACTGGACG
CGGAATTTGATGCCATCATGCAACGTCATGAACACACAATTGAAGCGTTGACTGATCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A9LK42


Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References