Detailed information of TA system TA203056

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2437406..2437631
• Replicon: chromosome
• Accession: NZ_CP075122
• Organism: Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051827

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: BCA48_RS11760
• Protein ID: WP_000813254.1
• Coordinates: 2437406..2437561 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2437573..2437631 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCA48_RS11725	2432513..2432794	-	282	WP_000445513.1	phage holin family protein	-
BCA48_RS11730	2432784..2432972	-	189	WP_001688615.1	putative holin	-
BCA48_RS11735	2432966..2433289	-	324	Protein_2312	tellurite/colicin resistance protein	-
BCA48_RS11740	2435460..2435996	-	537	WP_000640113.1	DUF1133 family protein	-
BCA48_RS11745	2435993..2436283	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
BCA48_RS11750	2436283..2436882	-	600	WP_000940751.1	DUF1367 family protein	-
BCA48_RS11755	2436945..2437115	-	171	WP_000734094.1	hypothetical protein	-
BCA48_RS11760	2437406..2437561	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2437573..2437631	+	59	-	-	Antitoxin
BCA48_RS11765	2437988..2438920	+	933	WP_000556389.1	hypothetical protein	-
BCA48_RS11770	2438917..2439471	+	555	WP_001033796.1	hypothetical protein	-
BCA48_RS11775	2439633..2439962	-	330	WP_001676916.1	DUF977 family protein	-
BCA48_RS23355	2440006..2440053	-	48	Protein_2321	hypothetical protein	-
BCA48_RS11785	2440235..2440702	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
BCA48_RS11790	2441087..2441242	+	156	WP_085981757.1	DUF1391 family protein	-
BCA48_RS11795	2441350..2441871	-	522	WP_000004762.1	super-infection exclusion protein B	-
BCA48_RS11800	2442309..2442530	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2431971..2443842	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T203056 WP_000813254.1 NZ_CP075122:c2437561-2437406 [Salmonella enterica subsp. enterica serovar Enteritidis]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T203056 NZ_CP099871:297486-298013 [Escherichia albertii]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTTTGCGAGCGTATATCCTTTGTAGCAACACTC
CAGAACGTCAGGTCCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTCACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCATTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCTCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCGTTGGTTGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACTAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT203056 NZ_CP075122:2437573-2437631 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin