Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4490027..4490781 | Replicon | chromosome |
| Accession | NZ_CP075118 | ||
| Organism | Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5RFE2 |
| Locus tag | BCB09_RS21665 | Protein ID | WP_000558168.1 |
| Coordinates | 4490027..4490338 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | BCB09_RS21670 | Protein ID | WP_001259009.1 |
| Coordinates | 4490335..4490781 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BCB09_RS21635 (4485685) | 4485685..4486587 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| BCB09_RS21640 (4486584) | 4486584..4487219 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| BCB09_RS21645 (4487216) | 4487216..4488145 | + | 930 | WP_000027736.1 | formate dehydrogenase accessory protein FdhE | - |
| BCB09_RS21650 (4488192) | 4488192..4488482 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| BCB09_RS21655 (4488483) | 4488483..4488794 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| BCB09_RS21660 (4489012) | 4489012..4489941 | + | 930 | WP_001127705.1 | alpha/beta hydrolase | - |
| BCB09_RS21665 (4490027) | 4490027..4490338 | + | 312 | WP_000558168.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| BCB09_RS21670 (4490335) | 4490335..4490781 | + | 447 | WP_001259009.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| BCB09_RS21675 (4490796) | 4490796..4491737 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| BCB09_RS21680 (4491782) | 4491782..4492219 | - | 438 | WP_000560968.1 | D-aminoacyl-tRNA deacylase | - |
| BCB09_RS21685 (4492216) | 4492216..4493088 | - | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| BCB09_RS21690 (4493082) | 4493082..4493681 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| BCB09_RS21695 (4493872) | 4493872..4494675 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| BCB09_RS21700 (4494709) | 4494709..4495605 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12324.26 Da Isoelectric Point: 9.3143
>T203021 WP_000558168.1 NZ_CP075118:4490027-4490338 [Salmonella enterica subsp. enterica serovar Enteritidis]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE
Download Length: 312 bp
>T203021 NZ_CP099834:4218656-4218994 [Klebsiella quasipneumoniae]
ATGAAAACTCTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTGCTCGTCTGGCAAACGCTACTTACACG
CCTGCTGGAGCAACACTATGGCCTTACCCTGAATGATACGCCGTTCAGTGATGAGAACGTTATTCAGGAGCATATCAACG
ACGGTATCACGCTGGCGGATGCCATTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTTAAC
TGTCAGGAGCAGTCCCCTTACCTTCGGGCGGTAGATATTTTACGGGCACGACAGGCAACCGGCCTGCTGCGGCAACGCCA
TCATCCTTCGGCACGCTGA
ATGAAAACTCTTCCTGCAAATCAGCGGGTGGCGAAGCCATGCCCGCCGCCTGTGCTCGTCTGGCAAACGCTACTTACACG
CCTGCTGGAGCAACACTATGGCCTTACCCTGAATGATACGCCGTTCAGTGATGAGAACGTTATTCAGGAGCATATCAACG
ACGGTATCACGCTGGCGGATGCCATTAACTTTCTGGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGGTTTAAC
TGTCAGGAGCAGTCCCCTTACCTTCGGGCGGTAGATATTTTACGGGCACGACAGGCAACCGGCCTGCTGCGGCAACGCCA
TCATCCTTCGGCACGCTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16720.06 Da Isoelectric Point: 6.6451
>AT203021 WP_001259009.1 NZ_CP075118:4490335-4490781 [Salmonella enterica subsp. enterica serovar Enteritidis]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT203021 NZ_CP099834:4218302-4218631 [Klebsiella quasipneumoniae]
ATGGATAAAGAAACCGACACAGTACGGTGGGGACTCAACCGACCCGGTTCTCCTCAACTTGGTGCACGTCTGGTACAGGA
AGGCAACCGCCTGCATTATTTAGCTGACCGCGCCGGAACAACTGGCGCGTTCAATGAAGAAGAGTGTCACCAGTTGAATA
GCGCATTTCCGCACTTTATAGAGCAGATGGAATTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCACATCGCGTC
ACTCTGTACCACAACGAACTGACCTGTGAAGCGGATACGCTCGGTAGCTGTGGCTACGTTTATATCGCTATCTATCCCAC
TCAACGTTAA
ATGGATAAAGAAACCGACACAGTACGGTGGGGACTCAACCGACCCGGTTCTCCTCAACTTGGTGCACGTCTGGTACAGGA
AGGCAACCGCCTGCATTATTTAGCTGACCGCGCCGGAACAACTGGCGCGTTCAATGAAGAAGAGTGTCACCAGTTGAATA
GCGCATTTCCGCACTTTATAGAGCAGATGGAATTGATGCTGCTCTCTGGTGAGCTTAACCCCCGCCATGCACATCGCGTC
ACTCTGTACCACAACGAACTGACCTGTGAAGCGGATACGCTCGGTAGCTGTGGCTACGTTTATATCGCTATCTATCCCAC
TCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|