Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4179144..4179925 Replicon chromosome
Accession NZ_CP075118
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN051890

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag BCB09_RS20310 Protein ID WP_000626100.1
Coordinates 4179144..4179635 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag BCB09_RS20315 Protein ID WP_001110452.1
Coordinates 4179632..4179925 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCB09_RS20275 (4174604) 4174604..4174951 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
BCB09_RS20280 (4174927) 4174927..4176630 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
BCB09_RS20285 (4176667) 4176667..4177242 + 576 WP_001188509.1 transcriptional regulator -
BCB09_RS20295 (4177513) 4177513..4177587 - 75 Protein_3984 helix-turn-helix domain-containing protein -
BCB09_RS20300 (4177967) 4177967..4178044 + 78 Protein_3985 porin family protein -
BCB09_RS20305 (4178144) 4178144..4178896 + 753 WP_000842433.1 non-specific acid phosphatase -
BCB09_RS20310 (4179144) 4179144..4179635 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
BCB09_RS20315 (4179632) 4179632..4179925 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
BCB09_RS20320 (4180242) 4180242..4180463 + 222 WP_001576552.1 hypothetical protein -
BCB09_RS20325 (4180729) 4180729..4181604 + 876 WP_000921676.1 AraC family transcriptional regulator -
BCB09_RS20330 (4181601) 4181601..4181888 + 288 WP_001541332.1 transcriptional regulator RtsB -
BCB09_RS20335 (4181881) 4181881..4182189 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
BCB09_RS20340 (4182188) 4182188..4182436 + 249 Protein_3993 Ig-like domain-containing protein -
BCB09_RS23225 (4182548) 4182548..4182679 + 132 Protein_3994 hypothetical protein -
BCB09_RS20345 (4182973) 4182973..4183878 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T203019 WP_000626100.1 NZ_CP075118:c4179635-4179144 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T203019 NZ_CP099834:c3914928-3914611 [Klebsiella quasipneumoniae]
ATGTTCAGAATGGTTGTGCACGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGGCCATTGTCCAGGCGAAGATGATCAG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGATAGTAAACCGCTGGGGCAGGGGCTATTCGAAA
TTCGGGCGTTAGGTTCGGTACAGGGGCGGGGGATTTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT203019 WP_001110452.1 NZ_CP075118:c4179925-4179632 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT203019 NZ_CP099834:c3914618-3914331 [Klebsiella quasipneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACGGAACTGCTCAGCCAGCCTGAGGTTCAGGCTGCGTTCGATGC
GCAAGAACGTCAACATCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCAACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References