Detailed information of TA system TA202716

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1933219..1933444
• Replicon: chromosome
• Accession: NZ_CP075037
• Organism: Salmonella enterica subsp. enterica serovar Give strain CFSAN012622

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: GJ28_RS09235
• Protein ID: WP_000813254.1
• Coordinates: 1933289..1933444 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1933219..1933277 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GJ28_RS23085	1928642..1928950	+	309	Protein_1800	DUF1376 domain-containing protein	-
GJ28_RS09200	1928957..1929703	+	747	WP_031571034.1	ATP-binding protein	-
GJ28_RS09205	1929734..1930129	+	396	WP_031571036.1	DUF977 family protein	-
GJ28_RS09210	1930126..1930416	+	291	WP_031571038.1	DUF4406 domain-containing protein	-
GJ28_RS09215	1930413..1930694	+	282	WP_031571041.1	DUF4752 family protein	-
GJ28_RS23090	1930687..1930947	+	261	WP_072010171.1	hypothetical protein	-
GJ28_RS09220	1930934..1931245	+	312	WP_031571044.1	hypothetical protein	-
GJ28_RS09225	1931379..1931933	-	555	WP_031571048.1	hypothetical protein	-
GJ28_RS09230	1931930..1932862	-	933	WP_000556389.1	hypothetical protein	-
-	1933219..1933277	-	59	-	-	Antitoxin
GJ28_RS09235	1933289..1933444	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
GJ28_RS09240	1933735..1933905	+	171	WP_031615787.1	hypothetical protein	-
GJ28_RS09245	1933968..1934567	+	600	WP_031571053.1	DUF1367 family protein	-
GJ28_RS09250	1934567..1934857	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
GJ28_RS09255	1934854..1935408	+	555	WP_031571056.1	DUF1133 family protein	-
GJ28_RS09260	1935681..1936247	+	567	WP_031571058.1	ORF6N domain-containing protein	-
GJ28_RS09275	1937815..1938240	+	426	WP_031571060.1	tellurite resistance TerB family protein	-
GJ28_RS09280	1938237..1938389	+	153	WP_031615788.1	DUF3927 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1912364..2014996	102632

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T202716 WP_000813254.1 NZ_CP075037:1933289-1933444 [Salmonella enterica subsp. enterica serovar Give]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T202716 NZ_CP099590:c3659051-3658653 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT202716 NZ_CP075037:c1933277-1933219 [Salmonella enterica subsp. enterica serovar Give]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin