Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 508135..508772 Replicon chromosome
Accession NZ_CP074685
Organism Bacillus velezensis strain VTX9

Toxin (Protein)


Gene name mazF Uniprot ID G4NU33
Locus tag KH263_RS02435 Protein ID WP_003156187.1
Coordinates 508422..508772 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID I2HMS5
Locus tag KH263_RS02430 Protein ID WP_003156188.1
Coordinates 508135..508416 (+) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KH263_RS02410 (KH263_02410) 504500..505099 - 600 WP_003156193.1 rhomboid family intramembrane serine protease -
KH263_RS02415 (KH263_02415) 505192..505557 + 366 WP_014304402.1 holo-ACP synthase -
KH263_RS02420 (KH263_02420) 505722..506729 + 1008 WP_003156191.1 outer membrane lipoprotein carrier protein LolA -
KH263_RS02425 (KH263_02425) 506846..508015 + 1170 WP_003156189.1 alanine racemase -
KH263_RS02430 (KH263_02430) 508135..508416 + 282 WP_003156188.1 type II toxin-antitoxin system antitoxin EndoAI Antitoxin
KH263_RS02435 (KH263_02435) 508422..508772 + 351 WP_003156187.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
KH263_RS02440 (KH263_02440) 508890..509711 + 822 WP_014304404.1 STAS domain-containing protein -
KH263_RS02445 (KH263_02445) 509716..510081 + 366 WP_003156180.1 RsbT antagonist protein RsbS -
KH263_RS02450 (KH263_02450) 510084..510485 + 402 WP_003156178.1 anti-sigma regulatory factor -
KH263_RS02455 (KH263_02455) 510497..511504 + 1008 WP_003156177.1 PP2C family protein-serine/threonine phosphatase -
KH263_RS02460 (KH263_02460) 511568..511897 + 330 WP_003156176.1 anti-sigma factor antagonist RsbV -
KH263_RS02465 (KH263_02465) 511894..512376 + 483 WP_003156173.1 anti-sigma B factor RsbW -
KH263_RS02470 (KH263_02470) 512342..513130 + 789 WP_003156171.1 RNA polymerase sigma factor SigB -
KH263_RS02475 (KH263_02475) 513130..513732 + 603 WP_003156170.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin

(12-45)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12977.98 Da        Isoelectric Point: 4.8781

>T202654 WP_003156187.1 NZ_CP074685:508422-508772 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF

Download         Length: 351 bp

>T202654 NZ_CP099575:c5957027-5956800 [Pseudomonas kermanshahensis]
ATGCGCAGTCGTGAAGTAATTCAGCTTATCGAGGCAGATGGGTGGTACGAAGTAGAGGTGAAGGGCAGCCATCACCAGTT
CAGGCACCCAACCAAAAGGGGGAGGGTGACGGTTCCCCACCCTAAGAGCGATCTGCCTAAGGGCACTGTACATAGCATCT
TGAAGCAAGCTGGGCTGAAGCAGCCTAATGGCTCCAACAGCTCAAGTACCAGTGGAGACACGCAATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10562.92 Da        Isoelectric Point: 6.4706

>AT202654 WP_003156188.1 NZ_CP074685:508135-508416 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG

Download         Length: 282 bp

>AT202654 NZ_CP099575:c5956803-5956396 [Pseudomonas kermanshahensis]
ATGAAATTTCCGGTCGTATTGCACAAAGACGCTGATTCGGACTACGGGGTGACCGTTCCTGATGTTCCTGGCTGCTTTTC
AGCAGGCGCCAGTGTCTCTCAGGCGTTGGAGAATGTTCAGGAGGCACTGGCGTTACATTTTGAAGGTCTGGTTGCCGATA
ACGAAGCGTTACCGCAGGCGCAAGAGATCGATGTTCATGTGGCTAACCCCGATTACCAAGGTGGGGTCTGGGCGGTCGTG
GACTTCGATGTGACCCCCTACCTTGGCAAGGCAGTGCGATTCAATGCGACGCTGCCGGAAAATTTGTTGCAACGGATCGA
TGAGAAGGTAAAGCGCGACCATAGGTATGCATCGCGTTCCGGATTTTTAGCATCGGCAGCGTTGCGAGAGCTGGCAATCG
CACACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MDX
PDB 4ME7
PDB 1NE8


Antitoxin

Source ID Structure
AlphaFold DB I2HMS5

References