Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4222230..4222746 Replicon chromosome
Accession NZ_CP074663
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CFSAN008081

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag BG493_RS20495 Protein ID WP_000220578.1
Coordinates 4222230..4222514 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag BG493_RS20500 Protein ID WP_000212724.1
Coordinates 4222504..4222746 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BG493_RS20480 (4217442) 4217442..4219094 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
BG493_RS20485 (4219503) 4219503..4221641 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
BG493_RS20490 (4221762) 4221762..4222226 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BG493_RS20495 (4222230) 4222230..4222514 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BG493_RS20500 (4222504) 4222504..4222746 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BG493_RS20505 (4222824) 4222824..4224737 - 1914 WP_001212137.1 BglG family transcription antiterminator -
BG493_RS20510 (4224754) 4224754..4225494 - 741 WP_000779263.1 KDGP aldolase family protein -
BG493_RS20515 (4225491) 4225491..4226609 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
BG493_RS20520 (4226593) 4226593..4227726 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T202584 WP_000220578.1 NZ_CP074663:c4222514-4222230 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T202584 NZ_CP099511:3284042-3284353 [Lelliottia amnigena]
ATGCACGTCATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAATCACTACCCAAACGATTCGTTAGCCCTTCTGGCGTTGTA
TCGCTTACTCCGTGAGACAGATTTTATTTCACCGACAGAACTGAGAACGTTAATACCGAGTCTGGATAATTTTAAGTATC
GAAGTAAATGGTGGGTAATAGATGTGGGTGGCAATAACTTGAGGATTGTCGCTTACATCAATTTTGTGAATAAACGCTTT
TACGTGAAGCATATCGTCACCCACTCTGAATACGATAAGTTGAACCGCTACTACAGGGAAAACAAACAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT202584 WP_000212724.1 NZ_CP074663:c4222746-4222504 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT202584 NZ_CP099511:3284350-3284769 [Lelliottia amnigena]
ATGATCGCTAATACAGCAAGAGCCATTGAGGCCACCAAACAACTCGTCGATGCCGTCCCTTTCCTGGGGGGCAGTTCTTC
AGAGAGTGATTATCGCGAAGCCCTGGCGCTAGTGGATTATCTGATCGAGAACGACGATGAAAATCCCCTGATTGACTTCC
TCGCGAGCAAAATTGCCGACTATGAAAATAATAGCGACCGCTTCGCTGAGTTTAATAAATCTGTCGCTGAAATGCCTGTC
GGCGTTGCTCTGCTGCGCACGCTGATCGATCAGTACAAGCTTTCTTACGCCGATCTGAAAGAAGAGATTGGTTCGAAATC
GCTGGTCAGCCAGATCTTATCCGGACAACGCTCTCTGACCATTACCCACATTAAAGCGCTTTCTGCACGCTTCGGCGTGA
GACCGGAATGGTTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References