Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4168274..4169055 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag A9D71_RS20260 Protein ID WP_000626100.1
Coordinates 4168274..4168765 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag A9D71_RS20265 Protein ID WP_001110452.1
Coordinates 4168762..4169055 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS20225 (4163734) 4163734..4164081 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
A9D71_RS20230 (4164057) 4164057..4165760 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
A9D71_RS20235 (4165797) 4165797..4166372 + 576 WP_001188509.1 transcriptional regulator -
A9D71_RS20245 (4166643) 4166643..4166717 - 75 Protein_3971 helix-turn-helix domain-containing protein -
A9D71_RS20250 (4167097) 4167097..4167174 + 78 Protein_3972 porin family protein -
A9D71_RS20255 (4167274) 4167274..4168026 + 753 WP_000842433.1 non-specific acid phosphatase -
A9D71_RS20260 (4168274) 4168274..4168765 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
A9D71_RS20265 (4168762) 4168762..4169055 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
A9D71_RS20270 (4169372) 4169372..4169593 + 222 WP_001576552.1 hypothetical protein -
A9D71_RS20275 (4169859) 4169859..4170734 + 876 WP_000921676.1 AraC family transcriptional regulator -
A9D71_RS20280 (4170731) 4170731..4171018 + 288 WP_001541332.1 transcriptional regulator RtsB -
A9D71_RS20285 (4171011) 4171011..4171319 - 309 WP_072095651.1 ABC transporter ATP-binding protein -
A9D71_RS20290 (4171318) 4171318..4171566 + 249 Protein_3980 Ig-like domain-containing protein -
A9D71_RS23170 (4171678) 4171678..4171809 + 132 Protein_3981 hypothetical protein -
A9D71_RS20295 (4172103) 4172103..4173008 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T202560 WP_000626100.1 NZ_CP074661:c4168765-4168274 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T202560 NZ_CP099504:2441324-2441476 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT202560 WP_001110452.1 NZ_CP074661:c4169055-4168762 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT202560 NZ_CP099504:2440700-2441299 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References