Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3397678..3398298 Replicon chromosome
Accession NZ_CP074661
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain CFSAN008104

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag A9D71_RS16615 Protein ID WP_001280991.1
Coordinates 3398080..3398298 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag A9D71_RS16610 Protein ID WP_000344807.1
Coordinates 3397678..3398052 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A9D71_RS16600 (3392817) 3392817..3394010 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A9D71_RS16605 (3394033) 3394033..3397182 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
A9D71_RS16610 (3397678) 3397678..3398052 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
A9D71_RS16615 (3398080) 3398080..3398298 + 219 WP_001280991.1 HHA domain-containing protein Toxin
A9D71_RS16620 (3398477) 3398477..3399028 + 552 WP_001278793.1 maltose O-acetyltransferase -
A9D71_RS16625 (3399146) 3399146..3399616 + 471 WP_000136183.1 YlaC family protein -
A9D71_RS16630 (3399672) 3399672..3399812 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
A9D71_RS16635 (3399818) 3399818..3400078 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
A9D71_RS16640 (3400303) 3400303..3401853 + 1551 WP_000213140.1 EAL domain-containing protein -
A9D71_RS16650 (3402084) 3402084..3402473 + 390 WP_000961287.1 MGMT family protein -
A9D71_RS16655 (3402506) 3402506..3403075 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T202553 WP_001280991.1 NZ_CP074661:3398080-3398298 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T202553 NZ_CP099502:2594825-2595034 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT202553 WP_000344807.1 NZ_CP074661:3397678-3398052 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT202553 NZ_CP099502:2594520-2594813 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References