Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3640686..3641339 Replicon chromosome
Accession NZ_CP074585
Organism Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag KIH05_RS17395 Protein ID WP_000607073.1
Coordinates 3640686..3641075 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag KIH05_RS17400 Protein ID WP_001288210.1
Coordinates 3641082..3641339 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIH05_RS17380 (KIH05_17330) 3635806..3638001 - 2196 WP_001158905.1 TRAP transporter large permease subunit -
KIH05_RS17385 (KIH05_17335) 3638189..3638755 - 567 WP_000651536.1 rhombosortase -
KIH05_RS17390 (KIH05_17340) 3638834..3639916 - 1083 WP_000049103.1 hypothetical protein -
KIH05_RS17395 (KIH05_17345) 3640686..3641075 - 390 WP_000607073.1 membrane protein Toxin
KIH05_RS17400 (KIH05_17350) 3641082..3641339 - 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
KIH05_RS17405 (KIH05_17355) 3641527..3642699 + 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
KIH05_RS17410 (KIH05_17360) 3642749..3644239 - 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
KIH05_RS17415 (KIH05_17365) 3644421..3644798 - 378 WP_001216380.1 50S ribosomal protein L17 -
KIH05_RS17420 (KIH05_17370) 3644817..3645824 - 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T202495 WP_000607073.1 NZ_CP074585:c3641075-3640686 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T202495 NZ_CP099464:3578740-3579078 [Dolichospermum heterosporum TAC447]
ATGAAAATTTGGATTGATGCACAGTTACCTCCAACATTAGCAGATTGGATCACAAACACTTTTGCTATCGAAGCATTTTC
ATTAAAAGAAATTGGTTTACGTGATGCTAAAGATATTGATATTTTTGAAGCTGCCAAAATAGCTAATGTAATAATTATGA
CAAAAGATAGTGATTTTGTTGACTTGGTTTGTCGCTTGGGTACACCTCCGCAAATTATTTGGTTAACTTGTGGAAATGTT
ACTAATCGTAATTTGCGTCAACTTCTGAATTTCACTTTACATGATGCGTTGGAAAAATTACGCCAAGGAGAAATGATTGT
AGAAATCAATAAATCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT202495 WP_001288210.1 NZ_CP074585:c3641339-3641082 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT202495 NZ_CP099464:3578519-3578743 [Dolichospermum heterosporum TAC447]
ATGAATGAACTATTAACTCGAATCACACAAATACCTGGTCAATGTGGAGGTCGTCCTTGCATTCGGGGAATGAGAATTAG
AGTTAGCGACATTTTAGAAATGTTAGCAGAAAATGTCAGTGTAAATGAAATTTTAGAAGACTTTCCTGATTTAGAACTAG
AAGATATTCAGGCTTGTTTAATATTCGCTGCAAGACGTACTGATTTTGTTAGATTAACAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References