Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3871579..3872198 Replicon chromosome
Accession NZ_CP074446
Organism Klebsiella aerogenes strain S2_CRE2

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag KHV89_RS18240 Protein ID WP_015367918.1
Coordinates 3871980..3872198 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag KHV89_RS18235 Protein ID WP_015367917.1
Coordinates 3871579..3871953 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KHV89_RS18225 (3866738) 3866738..3867937 + 1200 WP_047038885.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KHV89_RS18230 (3867960) 3867960..3871106 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
KHV89_RS18235 (3871579) 3871579..3871953 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
KHV89_RS18240 (3871980) 3871980..3872198 + 219 WP_015367918.1 HHA domain-containing protein Toxin
KHV89_RS18245 (3872330) 3872330..3872893 + 564 WP_103825580.1 maltose O-acetyltransferase -
KHV89_RS18250 (3873019) 3873019..3873483 + 465 WP_015367920.1 YlaC family protein -
KHV89_RS18255 (3873458) 3873458..3874912 - 1455 WP_103825581.1 PLP-dependent aminotransferase family protein -
KHV89_RS18260 (3875015) 3875015..3875725 + 711 WP_015704607.1 GNAT family protein -
KHV89_RS18265 (3875722) 3875722..3875862 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KHV89_RS18270 (3875865) 3875865..3876125 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T202182 WP_015367918.1 NZ_CP074446:3871980-3872198 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T202182 NZ_CP099338:988248-988583 [Escherichia fergusonii]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGTGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT202182 WP_015367917.1 NZ_CP074446:3871579-3871953 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT202182 NZ_CP099338:988000-988248 [Escherichia fergusonii]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References