Detailed information of TA system TA202112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443971..2444196
• Replicon: chromosome
• Accession: NZ_CP074428
• Organism: Salmonella sp. SJTUF14523

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: KFD69_RS11825
• Protein ID: WP_000813254.1
• Coordinates: 2443971..2444126 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2444138..2444196 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFD69_RS11790	2439078..2439359	-	282	WP_000445513.1	phage holin family protein	-
KFD69_RS11795	2439349..2439537	-	189	WP_001688615.1	putative holin	-
KFD69_RS11800	2439531..2439854	-	324	Protein_2322	tellurite/colicin resistance protein	-
KFD69_RS11805	2442025..2442561	-	537	WP_000640113.1	DUF1133 family protein	-
KFD69_RS11810	2442558..2442848	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
KFD69_RS11815	2442848..2443447	-	600	WP_000940751.1	DUF1367 family protein	-
KFD69_RS11820	2443510..2443680	-	171	WP_000734094.1	hypothetical protein	-
KFD69_RS11825	2443971..2444126	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2444138..2444196	+	59	-	-	Antitoxin
KFD69_RS11830	2444553..2445485	+	933	WP_000556390.1	hypothetical protein	-
KFD69_RS11835	2445482..2446036	+	555	WP_001033796.1	hypothetical protein	-
KFD69_RS11840	2446198..2446527	-	330	WP_001676916.1	DUF977 family protein	-
KFD69_RS23815	2446571..2446618	-	48	Protein_2331	hypothetical protein	-
KFD69_RS11850	2446800..2447267	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
KFD69_RS11855	2447652..2447807	+	156	WP_085981757.1	DUF1391 family protein	-
KFD69_RS11860	2447915..2448436	-	522	WP_000004762.1	super-infection exclusion protein B	-
KFD69_RS11865	2448874..2449095	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438536..2450407	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T202112 WP_000813254.1 NZ_CP074428:c2444126-2443971 [Salmonella sp. SJTUF14523]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T202112 NZ_CP099316:2830971-2831150 [Enterobacter hormaechei]
ATGGATAGCAGGAATGCAATAGCAATGATAGAAGCCGATGGGTGGTATCTGGTGAGAGTTAAAGGCAGTCATCACCAGTT
CAAACACCCAACGAAAAAGGGGCTGGTAACGGTAAAGCATCCACAGAAAGACATACCGTTACCAACACTGAAAAGCATCA
AAAAACAGGCGGGGCTCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT202112 NZ_CP074428:2444138-2444196 [Salmonella sp. SJTUF14523]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin