Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 866120..866774 Replicon chromosome
Accession NZ_CP074354
Organism Escherichia coli strain XJ5.2

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KFQ11_RS04390 Protein ID WP_097346894.1
Coordinates 866367..866774 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KFQ11_RS04385 Protein ID WP_000354046.1
Coordinates 866120..866386 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFQ11_RS04360 (861289) 861289..862032 + 744 WP_000951948.1 SDR family oxidoreductase -
KFQ11_RS04365 (862089) 862089..863522 - 1434 WP_040062540.1 6-phospho-beta-glucosidase BglA -
KFQ11_RS04370 (863567) 863567..863878 + 312 WP_001182947.1 N(4)-acetylcytidine aminohydrolase -
KFQ11_RS04375 (864042) 864042..864701 + 660 WP_282318416.1 hemolysin III family protein -
KFQ11_RS04380 (864897) 864897..865877 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
KFQ11_RS04385 (866120) 866120..866386 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KFQ11_RS04390 (866367) 866367..866774 + 408 WP_097346894.1 protein YgfX Toxin
KFQ11_RS04395 (866814) 866814..867335 - 522 WP_001055874.1 flavodoxin FldB -
KFQ11_RS04400 (867447) 867447..868343 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KFQ11_RS04405 (868368) 868368..869078 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFQ11_RS04410 (869084) 869084..870817 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16005.88 Da        Isoelectric Point: 11.5202

>T201870 WP_097346894.1 NZ_CP074354:866367-866774 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLSMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T201870 NZ_CP098809:c1257773-1257354 [Ensifer adhaerens]
ATGATCGTCCTGGACACGAATGTCGTCTCGGAGGCGATGAAGCCGGCCCCGGATTTGGCCGTGCGCAATTGGTTGAATGA
CCAGGTAGCCGAAACCTTGTTTCTGTCCAGTGTAACGCTGGCGGAACTGCTGTTTGGCATCGCCGCGCTACCGGAGGGCC
GGCGCAAAAAGGCGTTGGCCGACACGCTTGATGGCCTGCTCGAACTGTTCGACGATCGCGTGTTGTCATTCGACCCTGCG
GCGGCTCGGCACTATGCGGACCTTACGGCAACCGCGCGAGCAGTGGGGAAGGGATTCCAGACGCCTGATGGATACATTGC
GGCTATTGCAGCCTCCAAGGGATTTACAATCGCGACCCGCGATACAAGTCCCTTTGAGGCGGCAGGAGTCCCCGTCGTCA
ATCCTTGGAACCACCTATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT201870 WP_000354046.1 NZ_CP074354:866120-866386 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT201870 NZ_CP098809:c1258024-1257770 [Ensifer adhaerens]
ATGGCTATCCTGACAGTACGAAATGTACCTGATGAAGTGCACCGGGCTTTGCGCGTCCGGGCGGCAAATCACGGCCGCAG
CACAGAGGCGGAAGTCCGCGAGATTCTGGAACGTGCGGTAAAGCCCGAACAGCGTATTCGCATCGGCGATGCCTTGGCTG
AGTTGAGCGGGCGGCTTGGCTTGACCAATGATGATTTTGAAGTGTTCGACCAGATGCAAGACAAAGCGCCGGCGGAACCG
ATGAGGTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References