Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 71347..71866 Replicon plasmid pJSRIV001_1
Accession NZ_CP074148
Organism Serratia sp. JSRIV001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KGP17_RS27775 Protein ID WP_223499778.1
Coordinates 71579..71866 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KGP17_RS27770 Protein ID WP_223499777.1
Coordinates 71347..71589 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP17_RS27745 (KGP17_27655) 66690..67037 - 348 WP_223499772.1 IS66 family insertion sequence element accessory protein TnpB -
KGP17_RS27750 (KGP17_27660) 67034..67639 - 606 WP_223499773.1 IS66-like element accessory protein TnpA -
KGP17_RS27755 (KGP17_27665) 67564..68298 - 735 WP_223499774.1 N-6 DNA methylase -
KGP17_RS27760 (KGP17_27670) 68871..69842 - 972 WP_223499775.1 ParB family protein -
KGP17_RS27765 (KGP17_27675) 69851..71044 - 1194 WP_223499776.1 AAA family ATPase -
KGP17_RS27770 (KGP17_27680) 71347..71589 + 243 WP_223499777.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KGP17_RS27775 (KGP17_27685) 71579..71866 + 288 WP_223499778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP17_RS27780 (KGP17_27690) 72116..72916 - 801 WP_223499828.1 tyrosine-type recombinase/integrase -
KGP17_RS27785 (KGP17_27695) 73766..74461 + 696 WP_223499779.1 IS6 family transposase -
KGP17_RS27790 (KGP17_27700) 74528..75388 - 861 WP_223499780.1 class I SAM-dependent methyltransferase -
KGP17_RS27795 (KGP17_27705) 75539..75706 + 168 Protein_96 transposase -
KGP17_RS27800 76253..76765 + 513 WP_223499781.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pilW 1..90433 90433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10979.92 Da        Isoelectric Point: 10.3023

>T201661 WP_223499778.1 NZ_CP074148:71579-71866 [Serratia sp. JSRIV001]
MTYKIDFDNAAFKEWKKLGETVRQQLKKKLAQIVEAPRVEANRLHSLPDCYKIKLRASGYRLVYKVEDETVVILVLAVGK
RERLEVYKAAATRLG

Download         Length: 288 bp

>T201661 NZ_CP098710:476778-477728 [Yersinia ruckeri]
ATGGATGATTTAACAAAGCTATTCCCAGATGTTGCTGATGCTCTGGGCATTGAATCTGTTTCAATTGTAGAAAAAGATTA
TTACATCGTTGAGTTATTACGATTGCTCCAGCCTATGGACTTTGACACGCATCAGCTGGTTTTTGCCGGTGGAACAGCAT
TGTCAAAAGCGGGTATATCTTTGAACAGGATGTCGGAAGACGTGGACATTAAGCTTGTCCCCGTCGCTGGTTTTACCCAG
CAATATTCCAGAGGCCAGCGTAAAGACATTCGTAAGGGTATTATTCGGACCGTTATCGAAACGATTACAGCTTCAGGTAC
GTTTCGCATGGATGAAGGGTATCCAAAGGTTACTCGTGATGAATATCGCTATAATGAAATTCCGGTGCGTTACCCGCAGG
AATATGTACAAGTTCCCTGCTTAAGGCCATTTATCAAACTGGAACTGATGGAAACGGATTTGCTTGAGGCTGCGGAAAAT
CGTGCTATTAGCTCCTTGGTAATGGATCTAACAAAGAAGGGCGAAGTAGTGAGGGCTTTCCCTTGCGCAACCATCGGTAG
CACGCAGGCTGAAAAGCTGATCTCGATGATGCGCAGAACGGCTGCAAGTATGCGTGATGTGGAACGTGCAGTGGATGAAT
CACTGGTACGTCATATCTACGATAATTTTTGTATTGTTAGAGAAAAAGGTGCTGACGTTCCTGTTTTGAAGCAATTCGTG
CAGGAATGCATTGAACAGGATATTGAACGTTACGGTGCTCAGTACCCTGAATTCTGCGAGTCGCCTGTCGAAGAACTAAA
AATGGGGCTGGAAGAACTCGTGAGCAATCCTGTTTATAAGGAACGCTATCTGCAATTCGTCACACCAATGGTCTTCGGTG
AAAGCCACGTTTCATGGGAAGAGGCCTATGCCTGTTTTCGCAAAACGGTATTGGATGTGGTTGATGCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8726.03 Da        Isoelectric Point: 4.3951

>AT201661 WP_223499777.1 NZ_CP074148:71347-71589 [Serratia sp. JSRIV001]
MGTMNIRIDDDLKARAGVALDGLGITASEAVRLVLEYVAQNNRLPVQVALLADEDADIIELARERLANPGKRIRVTLDDL

Download         Length: 243 bp

>AT201661 NZ_CP098710:476390-476785 [Yersinia ruckeri]
ATGACTACAAAAGCTCGTATTCAGTTACGACTGAAACGCTCAAAGCGTTATGTTTTCACTCGTGACGATTTCAAAGATCT
TGCTGGCTACGACCAAATTGGTAGAGCACTGCGTGAACTGGTGAAGGAAGGGCAGCTGCTGAAAGTAGGCTATGGCGTCT
ACACCAAAGCGCGGCAAAATGTGATTACCGGTAAGTTGATGCCTGCGGCTCCCGGAGGTTCGGCTGCGGTAGTGATTGAG
GCGTTGGAACGTCTGAAAGTGGATTACCGCTTGGTTGGAGCAACAAGCGCCTATAATAGCGGTAAATCCACTCAGATCCC
CGCTTCACTGGAAATCAAAACCTCACCACGTTTTAAGAGGACATTGTCAGTAGGGAGCAGCAAACTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References