Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 21530..22049 Replicon plasmid pJSRIV004_1
Accession NZ_CP074141
Organism Serratia sp. JSRIV004

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KGP21_RS29010 Protein ID WP_223499778.1
Coordinates 21530..21817 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KGP21_RS29015 Protein ID WP_223499777.1
Coordinates 21807..22049 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGP21_RS28985 16631..17143 - 513 WP_223499781.1 hypothetical protein -
KGP21_RS28990 (KGP21_28895) 17690..17857 - 168 Protein_23 transposase -
KGP21_RS28995 (KGP21_28900) 18008..18868 + 861 WP_223499780.1 class I SAM-dependent methyltransferase -
KGP21_RS29000 (KGP21_28905) 18935..19630 - 696 WP_223499779.1 IS6 family transposase -
KGP21_RS29005 (KGP21_28910) 20480..21280 + 801 WP_223499828.1 tyrosine-type recombinase/integrase -
KGP21_RS29010 (KGP21_28915) 21530..21817 - 288 WP_223499778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGP21_RS29015 (KGP21_28920) 21807..22049 - 243 WP_223499777.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KGP21_RS29020 (KGP21_28925) 22352..23545 + 1194 WP_223499776.1 AAA family ATPase -
KGP21_RS29025 (KGP21_28930) 23554..24525 + 972 WP_223499775.1 ParB family protein -
KGP21_RS29030 (KGP21_28935) 25098..25832 + 735 WP_223499774.1 N-6 DNA methylase -
KGP21_RS29035 (KGP21_28940) 25757..26362 + 606 WP_223499773.1 IS66-like element accessory protein TnpA -
KGP21_RS29040 (KGP21_28945) 26359..26706 + 348 WP_223499772.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - fimD / fimC 1..114761 114761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10979.92 Da        Isoelectric Point: 10.3023

>T201601 WP_223499778.1 NZ_CP074141:c21817-21530 [Serratia sp. JSRIV004]
MTYKIDFDNAAFKEWKKLGETVRQQLKKKLAQIVEAPRVEANRLHSLPDCYKIKLRASGYRLVYKVEDETVVILVLAVGK
RERLEVYKAAATRLG

Download         Length: 288 bp

>T201601 NZ_CP098691:456005-456295 [Yersinia ruckeri]
ATGACCTTTAATATCGACTTTGACGAACGGGCATTAAAAGAATGGCACAAACTAGATAAAACTATCCGAGAGCAATTTAA
AAAGAAACTAAGAAAATTACAGGAAAATCCCTATATTGAGTCAGCACGTTTGCACGGTGATCTGGCTGGTTGTTTCAAAA
TAAAATTACGCGCATCTGGCTTTCGGTTGATTTACCAAGTTATCGATGAGGAGATTGTGATTTTGATCGTTGCTGTTGGT
AAACGGGAAGATGAAAAAGCTTATGATCTTGCCAAGAAGCGAATCCAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8726.03 Da        Isoelectric Point: 4.3951

>AT201601 WP_223499777.1 NZ_CP074141:c22049-21807 [Serratia sp. JSRIV004]
MGTMNIRIDDDLKARAGVALDGLGITASEAVRLVLEYVAQNNRLPVQVALLADEDADIIELARERLANPGKRIRVTLDDL

Download         Length: 243 bp

>AT201601 NZ_CP098691:455761-456015 [Yersinia ruckeri]
ATGAGTACTATCCAAATTCGTGTGGATGATGAACTGAAGAAAAGTGCATATCAGGCGTTTGAAAAACTGAATCTTTCGCC
TTCTGATGCACTACGCCTGTTCCTACGTTATGTTGCAGAGAACGAAAAGCTGCCTTTTTCAGAAGTATCCGTCATGGTCA
GTAATCAAGATGAGGATGCTGATATTTTGGCTGTTGTCCGTGAACGTTTGAAAAATCCTGCAAAGCGTATCAGAGTAAAT
ATTGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References